Increased oral nitric oxide in obstructive sleep apnoea

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Increased oral nitric oxide in obstructive sleep apnoea Beatrice Culla, Giuseppe Guida, Luisa Brussino, Antonella Tribolo, Alessandro Cicolin, Savino Sciascia, Iuliana Badiu, Sabrina Mietta, Caterina Bucca Respiratory Medicine Volume 104, Issue 2, Pages 316-320 (February 2010) DOI: 10.1016/j.rmed.2009.09.020 Copyright © 2009 Elsevier Ltd Terms and Conditions

Figure 1 Illustration of oral NO device. Siringe with NO-free air (1); two-way valve for delivery and withdrawal of air sample to and from the oral cavity and to the NO meter (2); wide-bore teflon tube (3); soft mouthpiece (4); Holed metal tube welded at a right angle to a shaped plate (5). Respiratory Medicine 2010 104, 316-320DOI: (10.1016/j.rmed.2009.09.020) Copyright © 2009 Elsevier Ltd Terms and Conditions

Figure 2 Geometric means and SD (bars) of oNO (A) and FENO (B) in patients with OSA compared to asthmatics (ASTHMA), chronic rhinitis and rhinosinusitis (CRS) and healthy subjects (HS). #p<0.001 OSA versus HS; ‡p<0.05 OSA versus ASTHMA; * p<0.05 OSA vs CRS. †p<0.05 ASTHMA versus CRS; ¥p<0.001 ASTHMA versus HS; ×p<0.05 CRS versus HS. Respiratory Medicine 2010 104, 316-320DOI: (10.1016/j.rmed.2009.09.020) Copyright © 2009 Elsevier Ltd Terms and Conditions

Figure 3 Correlation of oNO with AHI (A) and with SaO2<90% (B) in OSA patients. Respiratory Medicine 2010 104, 316-320DOI: (10.1016/j.rmed.2009.09.020) Copyright © 2009 Elsevier Ltd Terms and Conditions