Circadian rhythms and sleep in flies 报 告 人： Prof. Michael Rosbash Brandeis University; Howard Hughes Medical Institute 报告时间： 2016年10月18日(周二）上午10:00 报告地点： 9501会议室 主 持 人： 焦仁杰 研究员 报告人简介 Peter Gruber Chair in Neuroscience, March 2012 – present. Professor and Director of National Center for Behavioral Genomics, Brandeis University, January 2007 - present. Adjunct Professor, Department of Molecular Biology, The Massachusetts General Hospital, Boston, Massachusetts, June 1989-present. 【报告摘要】The Drosophila circadian clock functions within 75 pairs of brain neurons. We are expanding our understanding of their functions, including their contributions to behavior, their regulation of sleep and their circuitry. Methods include in vivo calcium monitoring of discrete neuronal groups over long time periods, suitable for circadian and sleep studies. We have also used optogenetic manipulation of individual neuronal groups. Finally, we have also used neuronal purification and deep sequencing “around the clock” to analyze and compare RNAs from several of these neurons as well as to identify molecules that contribute to these behaviors in a neuron-specific manner.