Disposition of Erlotinib and Its Metabolite OSI420 in a Patient with High Bilirubin Levels Case Rep Oncol 2013;6:602-608 - DOI:10.1159/000357211 Fig.

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Disposition of Erlotinib and Its Metabolite OSI420 in a Patient with High Bilirubin Levels Case Rep Oncol 2013;6:602-608 - DOI:10.1159/000357211 Fig. 1.a Course of laboratory parameters. b Observed plasma concentrations for erlotinib (circles) and OSI420 (squares) and simulated concentration time curve for erlotinib. The arrow indicates the time of the last erlotinib ingestion and the dashed line represents the required minimum cthrough of erlotinib for tyrosine kinase inhibition. BILI = Bilirubin. © 2013 S. Karger AG, Basel - CC BY-NC 3.0