Galactose.

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Presentation transcript:

Galactose

GALACTOSE GALACTOSE METABOLISM

GALACTOSE Galactose Galactose-1-phosphate ATP ADP Galactokinase Galactose Galactose-1-phosphate ATP ADP Galactose-1-phosphate uridyl transferase Galactose-1-p Glucose-1-p + UDP-glucose + UDP-galactose

GALACTOSE UMP UDP-glucose glucose-1-p glucose-6-p UDP-galactose UDP-glucose UMP UDP-glucose glucose-1-p glucose-6-p Glucose-6-phosphatase GLUCOSE

GALACTOSSEMIA: GALACTOSE This is a disease related to galactose metabolism. Clinical manifestations include: Prolonged neonatal jaundice mental retardation cataract

FRUCTOSE

FRUCTOSE ATP Fructose Fructokinase ADP Fructose-1-p Aldolase Dihdroxyacetone + Glyceraldehyde phosphate GLYCOLYTIC PATHWAY

FRUCTOSE ATP Glyceraldehyde-3-phosphate ADP Glyceraldehyde ATP ADP Glycerol ATP ATP ADP ADP 2-phosphoglycerate Glycerol-3-phosphate Dihydroxyacetone phosphate

Fructose intolerance: Deficeincy of enzyme Fructose-1-phosphate ALDOLASE. Clinical manifestations include: Hypoglycemia Vomitting hepatomegaly