A comprehensive outlook on intracerebral therapy of malignant gliomas

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A comprehensive outlook on intracerebral therapy of malignant gliomas Carlo Buonerba, Giuseppe Di Lorenzo, Alfredo Marinelli, Piera Federico, Giovannella Palmieri, Martina Imbimbo, Pio Conti, Gianfranco Peluso, Sabino De Placido, John H. Sampson  Critical Reviews in Oncology / Hematology  Volume 80, Issue 1, Pages 54-68 (October 2011) DOI: 10.1016/j.critrevonc.2010.09.001 Copyright © 2010 Elsevier Ireland Ltd Terms and Conditions

Fig. 1 Intracerebral implantation of Gliadel. Up to 8 wafers can be placed in the resection cavity after tumor excision. Reprinted by permission from Macmillan Publishers Ltd: Lesniak MS, Brem H. Targeted therapy for brain tumours. Nat Rev Drug Discov. 2004;3(June (6)):499–508. Copyright (2004). Critical Reviews in Oncology / Hematology 2011 80, 54-68DOI: (10.1016/j.critrevonc.2010.09.001) Copyright © 2010 Elsevier Ireland Ltd Terms and Conditions

Fig. 2 Computerized simulation on MRI images of predicted CED distribution volume (blue areas) on the basis of different catheter trajectories (yellow lines). Tridimensional representation of the predicted volume of distribution is also reported. Reproduced from Ref. [30], by permission of Oxford University Press. (For interpretation of the references to color in this figure legend, the reader is referred to the web version of the article.) Critical Reviews in Oncology / Hematology 2011 80, 54-68DOI: (10.1016/j.critrevonc.2010.09.001) Copyright © 2010 Elsevier Ireland Ltd Terms and Conditions