LIMITATIONS & FUTURE STUDIES

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LIMITATIONS & FUTURE STUDIES Psychotropic Medications and Changes in Weight in a Correctional Setting: The Impact on Women’s Health Madison L. Gates, PhD, Elizabeth Ferguson, MD, Thad Wilkins, MD, Darra Ballance, MLIS & Wonsuk Yoo, PhD Augusta University Institute of Public and Preventive Health, Augusta, Georgia INTRODUCTION RESULTS CONCLUSIONS Study population oversampled African Americans, men and offenders prescribed psychotropic agents. However, both populations were majority White, men, not prescribed psychotropic agents (Table 1). Studies with non-incarcerated populations have found a relationship between psychotropic agents and metabolic side effects, such as weight gain. Few studies have investigated the relationship between psychotropic agents associated with weight gain and offenders, despite data that 73% of women and 55% of men have a mental health problem and 15% are prescribed medications. This study investigated the relationship among changes in weight, psychotropic agents (i.e., antidepressants and antipsychotics) and incarceration in regard to potential disparities between women and men. There were gender differences in regard to antidepressant use where women gained significantly more weight compared to men; however, gender was not significant for antipsychotics (FGA and SGA). Psychotropic agents did not appear fully explanatory for differences in weight gain. Providing mental health treatment in a correctional environment is complex. Gender disparities, particularly to the detriment of women, is a recurrent finding in correctional health studies. Table 1. Population Distribution Variable Study Total p n (%) or Mean ± SD Race African American 897 (34.2) 3,192 (29.4) < .001 White 1,657 (63.2) 7,175 (66.2) 0.004 Gender Men 2,458 (93.8) 9,767 (90.1) Women 164 (6.3) 1074 (9.9) Age 40.20 ± 10.3 37.5 ± 11.5 Psychotropic 390 (14.9) 1,446 (13.3) 0.04 Women were prescribed antidepressants in higher proportions compared to men (χ2 = 58.3, p < .01). Proportions for antipsychotics were not significant (χ2 = 2.3, p = .13). There were no significant gender differences regarding who gained weight or not (Table 2). LIMITATIONS & FUTURE STUDIES Limitations Collected limited medication history Did not collect all data elements to evaluate metabolic syndrome Future Studies Potential moderating effects Effects of polypharmacy, medication switching and duration METHODS Table 2. Gender Changes in Weight Change in Weight (Y/N) No weight gain Weight gain Total Antidepressants* Female 16 (30.2) 37 (69.8) 53 (16.4) Male 119 (43.9) 152 (56.1) 271 (83.6) 135 (41.7) 189 (58.3) 324 Antipsychotics† 5 (31.3) 11 (68.8) 16 (9.3) 76 (48.7) 80 (51.3) 156 (90.7) 81 (47.1) 91 (52.9) 172 This retrospective study was approved by an institutional review board (IRB) at an academic health center and was conducted in collaboration with a Department of Corrections (DOC). Data collection: All health data were extracted from an EHR: (diagnoses, current medication, begin and end date for prescriptions, height and weight values). Inclusion criteria: Active records (i.e., offenders currently incarcerated) between June 1, 2005 and December 31, 2010; valid baseline and post weight observations; length of incarceration > 0. Analyses: SAS® 9.4 (SAS Institute, Cary, NC) was used to conduct statistical tests. Group comparisons, such as race, gender, medication indication, were made using either t-test or analysis of variance (ANOVA) or the Wilcoxon rank-sum test or Kruskal-Wallis test. REFERENCES Bak, M, Fransen, A, Janssen, J, van Os, J, & Drukker, M (2014). Almost all antipsychotics result in weight gain: a meta-analysis. PloS one, 9(4), e94112. Clarke, JG, & Waring, ME (2012). Overweight, obesity, and weight change among incarcerated women. Journal of correctional health care : the official journal of the National Commission on Correctional Health Care, 18(4), 285-292. Gates, ML, & Bradford, RK (2015). The impact of incarceration on obesity: are prisoners with chronic diseases becoming overweight and obese during their confinement? Journal of obesity, 2015, 532468. (Complete Reference list available upon request) *(χ2 = 3.4, p = .06); †(χ2 = 1.8, p = .18) Figure 1. Gender Changes in Weight (kg) Comparison In regard to changes in weight (kg), women on antidepressants gained more weight compared to men, but not for antipsychotics (Figure 1). Antidepressants (p < .01) Women gained 6.4 kg. Men gained 2.0 kg. Antipsychotics (p = .12) Women gained 8.8 kg. Men gained 1.6 kg. ACKNOWLEDGEMENTS We thank the Institute of Public and Preventive Health at Augusta University for providing support, time and resources to conduct this study.