Physics and Imaging in Radiation Oncology Dynamic contrast enhanced magnetic resonance imaging for hypoxia mapping and potential for brachytherapy targeting  Anna Li, Erlend Andersen, Christoffer Lervåg, Cathinka H. Julin, Heidi Lyng, Taran P. Hellebust, Eirik Malinen  Physics and Imaging in Radiation Oncology  Volume 2, Pages 1-6 (March 2017) DOI: 10.1016/j.phro.2017.03.002 Copyright © 2017 Terms and Conditions

Fig. 1 Center/width histograms (right) derived from the tumor images for LACC patients with generally low (A), intermediate (B) and high (C) ABrix values. The ABrix distribution within the tumors (left) and the frequency histograms (middle) are also shown. Physics and Imaging in Radiation Oncology 2017 2, 1-6DOI: (10.1016/j.phro.2017.03.002) Copyright © 2017 Terms and Conditions

Fig. 2 A) Plot showing the association between tumor volume fraction and progression free survival for given center/width combinations. The association is estimated by the slope β1 (see Eq. (2)) from the logistic regression analysis of 78 LACC patients. The cross indicates the point where the strongest association is found, i.e. for a center of 0.83 and a width of 1.56. The region within the solid black lines show the center/width combinations reaching significance (P<0.05) in the logistic regression. B) Plot of tumor volume fraction, obtained using a center/width of 0.83/1.56, against treatment outcome. The solid line represents a logistic regression of the data. n corresponds to the number of patients within a given bubble. Physics and Imaging in Radiation Oncology 2017 2, 1-6DOI: (10.1016/j.phro.2017.03.002) Copyright © 2017 Terms and Conditions

Fig. 3 The hypoxia gene score plotted against the BTV fraction derived from the center/width logistic regression analysis for 46 LACC patients. P-value and Pearson’s correlation coefficient are indicated. Physics and Imaging in Radiation Oncology 2017 2, 1-6DOI: (10.1016/j.phro.2017.03.002) Copyright © 2017 Terms and Conditions

Fig. 4 Kaplan-Meier curves for 78 LACC patients divided into two equally sized groups according to the BTV fraction derived from the center/width logistic regression analysis. Curves are shown for local control (left) and locoregional control (right). Stippled and solid lines correspond to patients with low and high BTV fraction, respectively. Physics and Imaging in Radiation Oncology 2017 2, 1-6DOI: (10.1016/j.phro.2017.03.002) Copyright © 2017 Terms and Conditions

Fig. 5 Brachytherapy planning of a LACC patient showing the Vienna ring applicator (cyan) with dwell positions given as red points. The resulting dose levels are shown overlaid the MR image basis for the axial (top left), sagittal (top right) and coronal (bottom) plane. The GTV is in red, the BTV in green, the bladder in blue and the rectum in purple. (For interpretation of the references to colour in this figure legend, the reader is referred to the web version of this article.) Physics and Imaging in Radiation Oncology 2017 2, 1-6DOI: (10.1016/j.phro.2017.03.002) Copyright © 2017 Terms and Conditions