Dose–Volume Relationships Associated With Temporal Lobe Radiation Necrosis After Skull Base Proton Beam Therapy Mark W. McDonald, MD, Okechukwu R. Linton,

Slides:

Advertisements

Similar presentations

A Quantitative Analysis of the Relationship Between Radiation Therapy Use and Travel Time Emma Liu, MM, Pablo Santibáñez, MM, Martin L. Puterman, PhD,

Advertisements

125I reimplantation in patients with poor initial dosimetry after prostate brachytherapy Mira Keyes, MD, Tom Pickles, MD, Alexander Agranovich, MD, Winkle.

Incidence of Late Rectal and Urinary Toxicities After Three-Dimensional Conformal Radiotherapy and Intensity-Modulated Radiotherapy for Localized Prostate.

Curative Treatment of Stage I Non-Small-Cell Lung Cancer in Patients With Severe COPD: Stereotactic Radiotherapy Outcomes and Systematic Review David.

Glucose Metabolism Gene Expression Patterns and Tumor Uptake of 18F- Fluorodeoxyglucose After Radiation Treatment George D. Wilson, PhD, Bryan J. Thibodeau,

COSMIC: A Regimen of Intensity Modulated Radiation Therapy Plus Dose-Escalated, Raster-Scanned Carbon Ion Boost for Malignant Salivary Gland Tumors: Results.

Correlation of 18F-FDG Avid Volumes on Pre–Radiation Therapy and Post–Radiation Therapy FDG PET Scans in Recurrent Lung Cancer Nadya Shusharina, PhD,

The Case for Prostate Brachytherapy in the Affordable Care Act Era

Benjamin D. Rosenbluth, M. D. , Victoria Serrano, B. S

Toxicity of Gamma Knife Radiosurgery in the Treatment of Intracranial Tumors in Patients With Collagen Vascular Diseases or Multiple Sclerosis Dot Lowell,

Late magnetic resonance imaging features of leukoencephalopathy in children with central nervous system tumours following high-dose methotrexate and neuraxis.

The Role of Diffusion-Weighted Magnetic Resonance Imaging in the Treatment Response Evaluation of Hepatocellular Carcinoma Patients Treated With Radiation.

Toward Magnetic Resonance–Only Simulation: Segmentation of Bone in MR for Radiation Therapy Verification of the Head Huan Yu, PhD, Curtis Caldwell, PhD,

Decline of Tumor Vascular Function as Assessed by Dynamic Contrast-Enhanced Magnetic Resonance Imaging Is Associated With Poor Responses to Radiation.

Validation of Heat Shock Protein 70 as a Tumor-Specific Biomarker for Monitoring the Outcome of Radiation Therapy in Tumor Mouse Models Christine Bayer,

The Use of Hormone Therapy Alone Versus Hormone Therapy and Radiation Therapy for Breast Cancer in Elderly Women: A Population-Based Study Alan M. Nichol,

Cost-Effectiveness Analysis of Stereotactic Body Radiotherapy and Radiofrequency Ablation for Medically Inoperable, Early-Stage Non–Small Cell Lung Cancer

Late Side Effects After Image Guided Intensity Modulated Radiation Therapy Compared to 3D-Conformal Radiation Therapy for Prostate Cancer: Results From.

18Fluorodeoxyglucose PET Is Prognostic of Progression-Free and Overall Survival in Locally Advanced Pancreas Cancer Treated With Stereotactic Radiotherapy

Dose-Volume Histogram Predictors of Chronic Gastrointestinal Complications After Radical Hysterectomy and Postoperative Concurrent Nedaplatin-Based Chemoradiation.

Leena Kankaanranta, M. D. , Tiina Seppälä, Ph. D. , Hanna Koivunoro, M

Intensity modulated radiation therapy for definitive treatment of paraortic relapse in patients with endometrial cancer Shervin M. Shirvani, MD, Ann.

Comparison of Nodal Risk Formula and MR Lymphography for Predicting Lymph Node Involvement in Prostate Cancer Willem M.L.L.G. Deserno, M.D., M.Sc., Oscar.

Lactate-Base 1H Magnetic Spectroscopy Does Not Predict Response and Outcomes in Patients With Stage IV Head and Neck Squamous Cell Carcinoma Q. Le, A.

Higher Biologically Effective Dose of Radiotherapy Is Associated With Improved Outcomes for Locally Advanced Non–Small Cell Lung Carcinoma Treated With.

Individualized Positron Emission Tomography–Based Isotoxic Accelerated Radiation Therapy Is Cost-Effective Compared With Conventional Radiation Therapy:

Close or Positive Margins After Mastectomy for DCIS: Pattern of Relapse and Potential Indications for Radiotherapy Afshin Rashtian, M.D., Shawn Iganej,

The impact of ipsilateral breast tumor recurrence on cause specific survival in DCIS patients treated with breast conserving therapy or mastectomy C.

Jerry D Slater, M. D. , Carl J Rossi, M. D. , Les T Yonemoto, M. D

Five-Year Biochemical Results, Toxicity, and Patient-Reported Quality of Life After Delivery of Dose-Escalated Image Guided Proton Therapy for Prostate.

Modern Radiation Therapy for Extranodal Lymphomas: Field and Dose Guidelines From the International Lymphoma Radiation Oncology Group Joachim Yahalom,

A New Model for Imaging and Radiation Therapy Quality Assurance in the National Clinical Trials Network of the National Cancer Institute Thomas J. FitzGerald,

Obituary and Tribute to John “Jack” Francis Fowler, PhD, DSc ( )

Continuing Risk of Ipsilateral Breast Relapse After Breast-Conserving Therapy at Long- Term Follow-up Bas Kreike, M.D., Augustinus A.M. Hart, M.Sc., Tony.

Frederiek M. Lever, MD, Irene M. Lips, MD, PhD, Sjoerd P. M

Timing of Radiation Therapy and Chemotherapy After Breast-Conserving Surgery for Node-Positive Breast Cancer: Long-Term Results From International Breast.

Jeffrey Bradley, MD Journal of Thoracic Oncology

Lifetime Increased Cancer Risk in Mice Following Exposure to Clinical Proton Beam– Generated Neutrons Leo E. Gerweck, PhD, Peigen Huang, MD, Hsiao-Ming.

Higher-Than-Conventional Radiation Doses in Localized Prostate Cancer Treatment: A Meta-analysis of Randomized, Controlled Trials Gustavo Arruda Viani,

Chad G. Rusthoven, MD, Christine F. Lauro, MD, Brian D

Salvage Stereotactic Body Radiotherapy (SBRT) Following In-Field Failure of Initial SBRT for Spinal Metastases Isabelle Thibault, MD, Mikki Campbell,

Adjuvant Therapy in High-Risk Stage III Cutaneous Melanoma

International Journal of Radiation Oncology • Biology • Physics

Vaginal Motion and Bladder and Rectal Volumes During Pelvic Intensity-Modulated Radiation Therapy After Hysterectomy Anuja Jhingran, M.D., Mohammad Salehpour,

Pierre Loulergue, MD, MSc, Agnès Guerre, MD

Radiation Therapy and Hearing Loss

High-Dose-Rate Brachytherapy Boost for Prostate Cancer: Comparison of Two Different Fractionation Schemes Tania Kaprealian, M.D., Vivian Weinberg, Ph.D.,

Should we irradiate a brain tumor in a patient with parkinsonism

Pierre Loulergue, MD, MSc, Agnès Guerre, MD

Image registration of sequential transparent photographs to localize and detect new versus recurrent tumors in dermatologic and Mohs micrographic surgery

All in His Head: An Unexpected Space-occupying Lesion

An Overlooked Cause of Hypokalemia

Volume growth of abdominal aortic aneurysms correlates with baseline volume and increasing finite element analysis-derived rupture risk Moritz Lindquist.

Dosimetric Benefits and Practical Pitfalls of Daily Online Adaptive MRI-Guided Stereotactic Radiation Therapy for Pancreatic Cancer Nancy El-Bared, MD,

Should we irradiate a brain tumor in a patient with parkinsonism

Surgical Management of Brain Metastases

Prophylactic Cranial Irradiation (PCI) versus Active MRI Surveillance for Small Cell Lung Cancer: The Case for Equipoise Chad G. Rusthoven, MD, Brian.

Prediction of asymptomatic abdominal aortic aneurysm expansion by means of rate of variation of C-reactive protein plasma levels Joaquin De Haro, MD,

Kiran Devisetty, MD, Joseph K. Salama, MD Journal of Thoracic Oncology

Detection of intraplaque hemorrhage by magnetic resonance imaging in symptomatic patients with mild to moderate carotid stenosis predicts recurrent neurological.

Clinical and radiobiological evaluation of a method for planning target volume generation dependent on organ-at-risk exclusions in magnetic resonance.

Jeffrey Bradley, MD Journal of Thoracic Oncology

Iwao Takanami, MD The Journal of Thoracic and Cardiovascular Surgery

Shirley J. Fearn, PhD, FRCS, Andrew J. Picton, BSc, Andrew J

Robert A. McCready, MD, Steven K. Miller, MD, Ronald C

Mark A. Marinella, MD, Kenneth Greene, MD Mayo Clinic Proceedings

Superior sulcus lung tumors: Impact of local control on survival

Todd J. Carpenter, MD, Kenneth E. Rosenzweig, MD

Analysis of pseudoprogression after proton or photon therapy of 99 patients with low grade and anaplastic glioma Julianna K. Bronk, Nandita Guha-Thakurta,

Fig. 1. Preoperative magnetic resonance imaging

Presentation transcript:

Dose–Volume Relationships Associated With Temporal Lobe Radiation Necrosis After Skull Base Proton Beam Therapy Mark W. McDonald, MD, Okechukwu R. Linton, MD, MBA, Cynthia S.J. Calley, MA International Journal of Radiation Oncology • Biology • Physics Volume 91, Issue 2, Pages 261-267 (February 2015) DOI: 10.1016/j.ijrobp.2014.10.011 Copyright © 2015 Elsevier Inc. Terms and Conditions

Fig. 1 An example of radiation necrosis in a patient treated for a clival chordoma. The left panel shows the presenting magnetic resonance imaging (MRI) with a clival and suprasellar T2 hyperintense tumor with bilateral cavernous sinus involvement and significant brainstem compression. The middle 2 panels show an axial and coronal image of the foci of asymptomatic radiation necrosis that developed in the left temporal lobe. MRI perfusion and spectroscopy were supportive of a diagnosis of radiation necrosis. Encephalomacia is noted in the right temporal lobe from prior surgery. The right panel shows the prior radiation dose superimposed on the MRI demonstrating radiation necrosis, which is transected by the prior 95% isodose line of therapy. Of note, based on its location at the time of treatment planning MRI, the maximum surface dose to the brainstem was 63 Gy (relative biological effectiveness). The patient remains without evidence of recurrent disease 3 years after radiation therapy. After initiation of pentoxifylline and Vitamin E, the area resolved on follow-up MRI. International Journal of Radiation Oncology • Biology • Physics 2015 91, 261-267DOI: (10.1016/j.ijrobp.2014.10.011) Copyright © 2015 Elsevier Inc. Terms and Conditions

Fig. 2 Mean dose–volume histogram for temporal lobes with and without radiation necrosis (any grade). The 95% confidence intervals for the mean of each curve are shown by the dashed lines. International Journal of Radiation Oncology • Biology • Physics 2015 91, 261-267DOI: (10.1016/j.ijrobp.2014.10.011) Copyright © 2015 Elsevier Inc. Terms and Conditions

Fig. 3 Median effective concentration volume risk analysis for temporal lobe radiation necrosis (any grade). Each curve is labeled for the absolute volume of temporal lobe exposed to a dose level in Gy (relative biological effectiveness). International Journal of Radiation Oncology • Biology • Physics 2015 91, 261-267DOI: (10.1016/j.ijrobp.2014.10.011) Copyright © 2015 Elsevier Inc. Terms and Conditions

Fig. 4 Absolute dose–absolute volume histogram curve predicted to have a 15% risk of any grade temporal lobe radiation necrosis. International Journal of Radiation Oncology • Biology • Physics 2015 91, 261-267DOI: (10.1016/j.ijrobp.2014.10.011) Copyright © 2015 Elsevier Inc. Terms and Conditions

Fig. 5 Semilog graph of the correlation between the absolute volume (aV) of temporal lobe receiving 40 Gy (y axis) and 70 Gy (x axis) for temporal lobes with and without subsequent development of any-grade radiation necrosis. Spearman rank-order correlation coefficient between aV40 and aV70 was 0.82, P<.01. International Journal of Radiation Oncology • Biology • Physics 2015 91, 261-267DOI: (10.1016/j.ijrobp.2014.10.011) Copyright © 2015 Elsevier Inc. Terms and Conditions