Beyond geometrical overlap: a Dosimetrical Evaluation of automated volumes Adaptation (DEA) in head and neck replanning Gian Carlo Mattiucci, Luca Boldrini,

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Beyond geometrical overlap: a Dosimetrical Evaluation of automated volumes Adaptation (DEA) in head and neck replanning Gian Carlo Mattiucci, Luca Boldrini, Lorenzo Placidi, Luigi Azario, Nicola Dinapoli, Giuditta Chiloiro, Danilo Pasini, Danila Piccari, Maria Antonietta Gambacorta, Mario Balducci, Giovanna Mantini, Vincenzo Valentini Technical Innovations and Patient Support in Radiation Oncology Volume 3, Pages 1-6 (September 2017) DOI: 10.1016/j.tipsro.2017.06.002 Copyright © 2017 The Authors Terms and Conditions

Fig. 1 IMRT plan realization and evaluation of plan A and B on benchmark PTV C. Technical Innovations and Patient Support in Radiation Oncology 2017 3, 1-6DOI: (10.1016/j.tipsro.2017.06.002) Copyright © 2017 The Authors Terms and Conditions

Fig. 2 Correlation between the DSI and mHD distance comparing the PTV C-PTV A (■) and PTV C-PTV B (○) overlap. Linear correlations between the DSI and mHD comparing PTV C-PTV A and PTV C-PTV B result, respectively, in a R2=0.84 and R2=0.82. Technical Innovations and Patient Support in Radiation Oncology 2017 3, 1-6DOI: (10.1016/j.tipsro.2017.06.002) Copyright © 2017 The Authors Terms and Conditions

Fig. 3 Correlation between the DSI and PTV volume reduction (cc) comparing PTV C and PTV A (■) and between PTV C and PTV B (○). Technical Innovations and Patient Support in Radiation Oncology 2017 3, 1-6DOI: (10.1016/j.tipsro.2017.06.002) Copyright © 2017 The Authors Terms and Conditions

Fig. 4 Correlation between the DSI and PTV C V95% coverage difference for Plan A (■) and for Plan B (○). Technical Innovations and Patient Support in Radiation Oncology 2017 3, 1-6DOI: (10.1016/j.tipsro.2017.06.002) Copyright © 2017 The Authors Terms and Conditions

Fig. 5 Correlation between the DSI and PTV C D99% coverage difference for Plan A (■) and for Plan B (○). Technical Innovations and Patient Support in Radiation Oncology 2017 3, 1-6DOI: (10.1016/j.tipsro.2017.06.002) Copyright © 2017 The Authors Terms and Conditions

Fig. 6 PTV dose coverage (isodose levels: 75–95%) for different plans. Left: plan A, middle: plan B, right: plan C (benchmark) on benchmark structure set. Technical Innovations and Patient Support in Radiation Oncology 2017 3, 1-6DOI: (10.1016/j.tipsro.2017.06.002) Copyright © 2017 The Authors Terms and Conditions