Fertility preservation in pre-pubertal girls with cancer: the role of ovarian tissue cryopreservation  W. Hamish B. Wallace, M.D., Thomas W. Kelsey, Ph.D., Richard A. Anderson, M.D.  Fertility and Sterility  Volume 105, Issue 1, Pages 6-12 (January 2016) DOI: 10.1016/j.fertnstert.2015.11.041 Copyright © 2016 American Society for Reproductive Medicine Terms and Conditions

Figure 1 Normative model for non-growing follicle (NGF) population. The best model for the establishment of the non-growing follicle population after conception, and the subsequent decline until age at menopause. CI = confidence interval. Reprinted with permission (19). Fertility and Sterility 2016 105, 6-12DOI: (10.1016/j.fertnstert.2015.11.041) Copyright © 2016 American Society for Reproductive Medicine Terms and Conditions

Figure 2 Rates of non-growing follicle (NGF) recruitment towards maturation. Illustrations of the absolute number of NGFs recruited per month, for ages from birth to 55 years, based on population decline predicted by the Asymmetric Double-Gaussian Cumulative model. (A) Recruitment for individuals whose decline is in line with the average age at menopause; maximum recruitment of 880 follicles per month occurs at 14 years 2 months. (B) Recruitment for individuals whose decline is in line with early age at menopause (the lower 95% prediction limit of the model); maximum recruitment of 104 follicles per month occurs at 14 years 2 months. (C) Recruitment in line with late age at menopause (the upper 95% prediction limit of the model); maximum recruitment of 7,520 follicles per month occurs at 14 years 2 months. Reprinted with permission (19). Fertility and Sterility 2016 105, 6-12DOI: (10.1016/j.fertnstert.2015.11.041) Copyright © 2016 American Society for Reproductive Medicine Terms and Conditions

Figure 3 The normal range for serum antimüllerian hormone (AMH) in girls and women. Red line, the log-unadjusted validated AMH model using Immunotech Beckman Coulter assay values. Blue line and green line, the 68% and 95% prediction limits for the model (plus and minus one and two standard deviations respectively). Reprinted with permission (21). Fertility and Sterility 2016 105, 6-12DOI: (10.1016/j.fertnstert.2015.11.041) Copyright © 2016 American Society for Reproductive Medicine Terms and Conditions

Figure 4 Cumulative probabilities of not having premature ovarian insufficiency. Reprinted with permission (40). Fertility and Sterility 2016 105, 6-12DOI: (10.1016/j.fertnstert.2015.11.041) Copyright © 2016 American Society for Reproductive Medicine Terms and Conditions