The human polysaccharide- and protein-specific immune response to Streptococcus pneumoniae is dependent on CD4+ T lymphocytes, CD14+ monocytes, and the.

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Presentation transcript:

The human polysaccharide- and protein-specific immune response to Streptococcus pneumoniae is dependent on CD4+ T lymphocytes, CD14+ monocytes, and the CD40– CD40 ligand interaction Leen Moens, PhD, Greet Wuyts, MLT, Louis Boon, PhD, Marcel T. den Hartog, PhD, Jan L. Ceuppens, MD, PhD, Xavier Bossuyt, MD, PhD Journal of Allergy and Clinical Immunology Volume 122, Issue 6, Pages 1231-1233 (December 2008) DOI: 10.1016/j.jaci.2008.09.006 Copyright © 2008 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 1 CD40L-expressing CD4+ T lymphocytes stimulate the human anti–caps-PS antibody response through interaction with CD40-expressing CD14+ mononuclear cells. SCID/SCID mice were reconstituted with (1) human PBMCs (n = 5); (2) purified CD19+ B lymphocytes and CD4+ T lymphocytes (n = 4); (3) purified CD19+ B lymphocytes, CD4+ T lymphocytes, and CD14+ monocytes in the presence of human polyclonal IgG (n = 4); or (4) anti-CD40 mAbs (n = 2). The purity of the cell populations was greater than 99% for all fractions. The mice were immunized with heat-inactivated S pneumoniae serotype 3. The absorbance values at serum dilution (1:100) are shown. The results shown are from 6 independent experiments. The error bars show the SD. ∗Statistically significant (P < .05, Mann-Whitney U test [Analyse-it for Microsoft Excel]). Journal of Allergy and Clinical Immunology 2008 122, 1231-1233DOI: (10.1016/j.jaci.2008.09.006) Copyright © 2008 American Academy of Allergy, Asthma & Immunology Terms and Conditions