An extremely rare case of thyroid malignancy from the non-Alpine region: Angiosarcoma Ömer Bayır, Demet Yılmazer, Reyhan Ersoy, Yasemin Akca, Güleser.

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An extremely rare case of thyroid malignancy from the non-Alpine region: Angiosarcoma Ömer Bayır, Demet Yılmazer, Reyhan Ersoy, Yasemin Akca, Güleser Saylam, Ünsal Han, Ali Özdek, Bekir Çakır, Mehmet Hakan Korkmaz International Journal of Surgery Case Reports Volume 19, Pages 92-96 (January 2016) DOI: 10.1016/j.ijscr.2015.12.028 Copyright © 2015 The Authors Terms and Conditions

Fig. 1 Preoperative neck CT images of the patient. The trachea is seen to be deviated to the left. Red arrow: thyroid gland featuring calcifications and extending into the retrosternal area, which cannot be clearly differentiated from the surrounding tissues. Yellow arrow: lymphadenopathies. International Journal of Surgery Case Reports 2016 19, 92-96DOI: (10.1016/j.ijscr.2015.12.028) Copyright © 2015 The Authors Terms and Conditions

Fig. 2 The image of the total thyroidectomy specimen of the patient. International Journal of Surgery Case Reports 2016 19, 92-96DOI: (10.1016/j.ijscr.2015.12.028) Copyright © 2015 The Authors Terms and Conditions

Fig. 3 The venography image of the patient performed after the development of the third hematoma. The right IJV is observed to be obliterated in inferior parts (r: right; white arrow: the obliterated area of the IJV). International Journal of Surgery Case Reports 2016 19, 92-96DOI: (10.1016/j.ijscr.2015.12.028) Copyright © 2015 The Authors Terms and Conditions

Fig. 4 Histopathological and immunohistochemical images of the patient: (a) vascular tumoral structures between thyroid follicles (H&E c40). (b) Vascular tumoral structures in the muscle tissues around the thyroid gland (H&E ×40). (c) CD31 positivity (×40). (d) CD34 positivity (×40). International Journal of Surgery Case Reports 2016 19, 92-96DOI: (10.1016/j.ijscr.2015.12.028) Copyright © 2015 The Authors Terms and Conditions

Fig. 5 Immunohistochemical images of the patient. (a) Vimentin positivity (×40). (b) Ki67 positivity (×40). (c) Thyroglobulin negativity (×40). (d) TTF-1 negativity (×40). International Journal of Surgery Case Reports 2016 19, 92-96DOI: (10.1016/j.ijscr.2015.12.028) Copyright © 2015 The Authors Terms and Conditions