Bioavailability of a drug from an immediate-release tablet containing 50 mg of drug given at 0, 4, and 8 hours compared to a single 150-mg drug dose given.

Slides:

Advertisements

Similar presentations

Selected bioavailability and pharmacokinetic calculations Dr. Osama A. A. Ahmed.

Advertisements

Pharmacokinetics & Pharmacodynamics of Controlled Release Systems Presented By: Govardhan.P Dept. of pharmaceutics, University College of Pharmaceutical.

 Modified drug release dosage forms:  These dosage forms are designed to release drugs in a controlled manner, at a predetermined rate, duration and.

Case studies Saila Antila, PhD WHO consultant Training workshop on Pharmaceutical Quality, Good Manufacturing Practice & Bioequivalence, Kiev

Drugs in the Body (1) Recurrence Relations A patient is given an initial dose of 50mg of a drug. Each hour the patient is given a 20mg tablet of the.

Pharmacokinetics of Drug Absorption Dr. Basavaraj K. Nanjwade M. Pharm., Ph. D Department of Pharmaceutics Faculty of Pharmacy Omer Al-Mukhtar University.

Test Undergraduate – 24 Questions: Multiple Choice, Fill-in and T/F – 3 Problems MS – 3 Questions: Multiple Choice, Fill-in and T/F – MS grade: Undergrad.

Downloaded from نور آغا ”محمدی“ سهراب عبدالله ”عطائی“ محمد اقبال محبوب الله ”دگروال“ سمیع الله ”گرده “ زبیر ”بنیادی“ عبدالمقسط.

CMS-1500 Outpatient Medical Service Claim Form

ACLS algorithm for bradycardia

Electrocardiogram of a patient with hyperkalemia

ACLS algorithm for asystole

Recording of fetal heart rate and uterine activity

Drug-metabolizing enzymes that exhibit clinically relevant genetic polymorphisms. Essentially all of the major human enzymes responsible for modification.

The LifeStat system is an example of a piston compression device

Negative-feedback control systems

An illustration of the different barriers that must be overcome to gain the approval of a new drug product through either New Drug Application (NDA) or.

Plasma drug concentration-time profiles after IV infusion

(Data from Rosenfeld RL. N Engl J Med 2005; 353:2578–2588.)

Small bowel Crohn disease.

(Reproduced from Maisels MJ. Why use homeopathic doses of phototherapy

Monoclonal antibody production

The fraction of drug absorbed using the Wagner–Nelson method may be used to distinguish between the first-order drug absorption rate of a conventional.

The fraction of drug absorbed using the Wagner–Nelson method may be used to distinguish between the first-order drug absorption rate of a conventional.

Biopharmaceutics of modified release drug products

Rodin, “The Kiss” (545 x 800). Accessed at

Depending on which drug coding system is used, cefazolin could be represented in a variety of different ways. Notice that the NDC codes are product specific,

Practicing sit-to-stand/sit-from-stand transfers using a variety of seating surfaces will better simulate a patient's home and community environment. Source:

Areas that are chronically excoriated can evolve into lichen simplex chronicus. Source: Atopic Dermatitis, Comprehensive Pediatric Hospital Medicine, 2e.

Responses to reduced plasma calcium concentration

An adolescent with a peripherally inserted central venous catheter (PICC line) in the right upper extremity. Source: Pediatric Acute-Care Hospital, Meeting.

Illustration of ways regression lines can differ

Reaction mechanism of the Michael addition reaction between a nucleophile and a polarized double bond. Source: Nucleophilic Substitution, Addition, and.

(A). Systemic infusion of opioids. (B) Epidural infusion of opioids

A standard epidural order form.

A tension pneumothorax should have been suspected based on the clinical scenario and the absence of breath sounds on the left. Emergency needle decompression.

Cutoff values used to determine low, medium, and high glycemic index foods. Also shown are sample foods for each index level. Source: Introduction to Basic.

Criteria used to determine breath types during mechanical ventilation

Effects of active metabolites of vitamin D (D), parathyroid hormone (PTH), calcitonin (CT), and fibroblast growth factor 23 (FGF23) on calcium and phosphorus.

In this Tai Chi form, the participant shifts the body-weight toward one leg while moving the arms. Source: Exercise for Impaired Balance, Therapeutic Exercise:

King of Hearts monitor. The device is attached to the patient and easily activated when symptoms arise. Record button is on top; out of view. The send.

(A) Simulation of propofol effect-site concentrations (Ce) that result from a bolus (2 mg/kg) and 1-hour infusion (150 mcg/kg/min) for a 53-year-old 155-cm.

Radiograph of a solitary plasmacytoma in the proximal femur of a 46-year-old man. Source: Chapter 5. Musculoskeletal Oncology, Current Diagnosis & Treatment.

(Reproduced with permission from Amato AA, Russell JA

Staging system for gastric carcinoma

Adapted from Aronson L. Twelve tips for teaching reflection at all levels of medical education. Med Teach. 2011;33(3):200–205. Source: EDUCATING FOR PROFESSIONALISM,

The action of xanthine oxidase in uric acid synthesis and metabolism of allopurinol. (Modified and reproduced, with permission, from Katzung BG, editor:

Only three distinct stereoisomers of 1,3-dimethylcyclohexane are possible. These include a pair of enantiomers (bottom) and a single achiral stereoisomer.

The 3-compartment pharmacokinetic model

Longitudinal view of the proximal plantar fascia as it originates from the calcaneus (CALC). Source: Musculoskeletal Ultrasound, CURRENT Diagnosis & Treatment:

BTP3822 BIOPHARMACEUTICS by

(A) Seat width of wheelchair should be slightly wider than the user's hip width. (B) Seat width measured on wheelchair. Source: Prevention and Treatment.

Semilog graph of the rate of drug elimination in a one-compartment model. Source: One-Compartment Open Model: Intravenous Bolus Administration, Applied.

This defibrillator device has been set to synchronized “SYNC” mode

Predictions of scaled weight based on lean body mass, fat-free mass,13 modified fat-free mass,16,17 ideal body weight, and pharmacokinetic (PK) mass14,15.

Principle of ion exchange in drug delivery systems

Drug product performance and generic drug product development

Small bowel obstruction

Number of uninsured persons in the United States, 1980 to 2014 (U. S

The large hepatic portal vein that collects blood from various segments of the GI tract also perfuses the liver. Source: Drug Elimination and Hepatic Clearance,

Copyright © 2004 The McGraw-Hill Companies, Inc. All rights reserved.

Copyright © 2004 The McGraw-Hill Companies, Inc. All rights reserved.

Copyright © 2004 The McGraw-Hill Companies, Inc. All rights reserved.

Selected Bioavailability and Pharmacokinetic Calculations

Copyright © 2004 The McGraw-Hill Companies, Inc. All rights reserved.

Copyright © 2004 The McGraw-Hill Companies, Inc. All rights reserved.

Copyright © 2004 The McGraw-Hill Companies, Inc. All rights reserved.

Copyright © 2004 The McGraw-Hill Companies, Inc. All rights reserved.

Copyright © 2004 The McGraw-Hill Companies, Inc. All rights reserved.

Copyright © 2004 The McGraw-Hill Companies, Inc. All rights reserved.

Presentation transcript:

Bioavailability of a drug from an immediate-release tablet containing 50 mg of drug given at 0, 4, and 8 hours compared to a single 150-mg drug dose given in an extended-release dosage form. The drug absorption rate constant from the immediate-release drug product is first order, whereas the drug absorption rate constant from the extended-release drug product is zero order. The drug is 100% bioavailable and the elimination half-life is constant. Source: Modified-Release Drug Products and Drug Devices, Applied Biopharmaceutics & Pharmacokinetics, 7e Citation: Shargel L, Yu AC. Applied Biopharmaceutics & Pharmacokinetics, 7e; 2016 Available at: http://accesspharmacy.mhmedical.com/DownloadImage.aspx?image=/data/books/1592/sha_ch19_f004.png&sec=100674054&BookID=1592&ChapterSecID=100674031&imagename= Accessed: November 04, 2017 Copyright © 2017 McGraw-Hill Education. All rights reserved