Replacement of PVP by Hyaluronan in ICSI

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Replacement of PVP by Hyaluronan in ICSI PVP is a fully undegradable organic compound which may have hazardous effect (Barak et al 2001) Hyaluronan (Hyaluronic acid) is a natural compound surrounding the oocyte at the time of fertilisation. It binds only to mature spermatozoa (Kovacs et al.2004) and so, allows to select the mature ones. A comparative study has been performed in 2003 Transfer on D3 after culture in ISM1 medium

Replacement of PVP by Hyaluronan in ICSI Hyaluronan PVP Patients 92 110 Age (Yrs) 33.6 33.6 Transfer rate 96% 94% (88/92) (105/110) No Embryos/tr 1.88 1.86 (166/88) (195/105)

Replacement of PVP by Hyaluronan in ICSI Hyaluronan PVP Clin Pregnancies 40 42 Implantation rate Clinical 28.3% 25.6% 47/166 50/195 Ongoing 25.3% 25.6% 42/166 48/195

Replacement of PVP by Hyaluronan in ICSI Hyaluronan offers a good opportunity to get rid of PVP It allows selection of the best spermatozoa, giving at least as good results as PVP

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