Demonstration of Calcitonin and Calmodulin by Immunoperoxidase in the Cystic Fibrosis Lung  Paul Wolf, M.D., Christopher Hall, M.D., J.P. Kilbourn, Ph.D.  CHEST  Volume 89, Issue 3, Pages 327-330 (March 1986) DOI: 10.1378/chest.89.3.327 Copyright © 1986 The American College of Chest Physicians Terms and Conditions

Figure 1 Immunoperoxidase calcitonin stain of autopsy section of cystic fibrosis lung demonstrating 4 + staining of pulmonary endocrine cells positive for calcitonin. Each bronchiole contained three to eight endocrine cells with 4+ staining. CHEST 1986 89, 327-330DOI: (10.1378/chest.89.3.327) Copyright © 1986 The American College of Chest Physicians Terms and Conditions

Figure 2 Immunoperoxidase calcitonin stain of autopsy section of normal lung or COPD lung demonstrating no staining for calcitonin in the pulmonary endocrine cells in the bronchioles. The 0 to 1 + staining of an occasional pulmonary endocrine cell was observed in ten normal bronchioles. CHEST 1986 89, 327-330DOI: (10.1378/chest.89.3.327) Copyright © 1986 The American College of Chest Physicians Terms and Conditions

Figure 3 Immunoperoxidase calmodulin stain of autopsy section of cystic fibrosis lung demonstrating 2+ staining of pneumocytes of lung alveolar cells for calmodulin and bronchiolar epithelium. CHEST 1986 89, 327-330DOI: (10.1378/chest.89.3.327) Copyright © 1986 The American College of Chest Physicians Terms and Conditions

Figure 4 Immunoperoxidase calmodulin stain of autopsy section of normal lung or COPD lung demonstrating 0 to faint minimal 1+ staining of pneumocytes of lung alveolar cells and bronchiolar epithelium for calmodulin. CHEST 1986 89, 327-330DOI: (10.1378/chest.89.3.327) Copyright © 1986 The American College of Chest Physicians Terms and Conditions

Figure 5 Chemical make-up of cystic fibrosis sputum in units of millimoles per liter. (Presented in Poster Session on July 31, 1984, at the annual meetings of the American Association of Clinical Chemistry, Washington, DC.8) CHEST 1986 89, 327-330DOI: (10.1378/chest.89.3.327) Copyright © 1986 The American College of Chest Physicians Terms and Conditions