Xenotransplantation of uterine leiomyoma in Wistar rats: a pilot study

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Xenotransplantation of uterine leiomyoma in Wistar rats: a pilot study Willane Bandeira de Sousa, João Batista Santos Garcia, João Nogueira Neto, Pablo Gustavo Ribeiro Furtado, Jonhnathan Adriano Araújo dos Anjos European Journal of Obstetrics and Gynecology and Reproductive Biology Volume 190, Pages 71-75 (July 2015) DOI: 10.1016/j.ejogrb.2015.04.012 Copyright © 2015 Elsevier Ireland Ltd Terms and Conditions

Fig. 1 (A) (group I) Implantation human uterine leiomyoma tissue into the peritoneal cavity via the abdomen (arrow); (B) (group II) the xenografts were transplanted subcutaneous (arrow). (C) Macroscopic aspect of a human uterine leiomyoma xenograft (arrow) in the parietal peritoneum (group I); (D) Macroscopic aspect of a human uterine leiomyoma xenograft (arrow) in subcutaneous tissue (group II). Both C and D images were taken four weeks after the transplant of human uterine leiomyoma in female Wistar rats that were immunosuppressed with mycophenolate mofetil (40mg/kg) and supplemented with estrogen (estradiol valerate) during the entire experiment. European Journal of Obstetrics and Gynecology and Reproductive Biology 2015 190, 71-75DOI: (10.1016/j.ejogrb.2015.04.012) Copyright © 2015 Elsevier Ireland Ltd Terms and Conditions

Fig. 2 Photomicrograph of a human leiomyoma xenograft in the peritoneum of a female Wistar rat (Group I) showing neovascularization (arrows) and the absence of cellular atypia after 14 days of immunosuppressant administration [mycophenolate mofetil (40mg/kg)] and estrogen supplementation (estradiol valerate). European Journal of Obstetrics and Gynecology and Reproductive Biology 2015 190, 71-75DOI: (10.1016/j.ejogrb.2015.04.012) Copyright © 2015 Elsevier Ireland Ltd Terms and Conditions

Fig. 3 Association between the examined variables (neovascularization and necrosis) in the human uterine leiomyoma xenograft four weeks after transplantation into the parietal peritoneum (Group I) or subcutaneous tissue (Group II) of female Wistar rats immunosuppressed with mycophenolate mofetil (40mg/kg) and supplemented with estrogen (estradiol valerate) throughout the entire experiment. European Journal of Obstetrics and Gynecology and Reproductive Biology 2015 190, 71-75DOI: (10.1016/j.ejogrb.2015.04.012) Copyright © 2015 Elsevier Ireland Ltd Terms and Conditions