Figure 2 Lack of changes in current properties between myocytes

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Figure 2 Lack of changes in current properties between myocytes Figure 2 Lack of changes in current properties between myocytes. (A) Traces of I<sub>CaL</sub> elicited by 10 mV incremental test pulses from –80 mV in myocytes with either large (left panel) or small (right panel) currents. Comparison of the current density–voltage relationships (B), activation and steady-state inactivation (C), in a group of current densities <2.5 pA/pF (open symbol) and >2.5 pA/pF (filled symbol). Each point is the mean ± SD of 10 myocytes. From: Downregulation of the calcium current in human right atrial myocytes from patients in sinus rhythm but with a high risk of atrial fibrillation Eur Heart J. 2008;29(9):1190-1197. doi:10.1093/eurheartj/ehn140 Eur Heart J | Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2008. For permissions please email: journals.permissions@oxfordjournals.org

Figure 1 Calcium current density varies between myocytes Figure 1 Calcium current density varies between myocytes. (A) Distribution of I<sub>CaL</sub> density recorded in 172 myocytes. Bars represent the number (n) of each of the I<sub>CaL</sub> current density measurements, normalized to the total number of measurements. (B) Peak current amplitude and (C) current density plotted against membrane capacitance showing no significant correlation between the two parameters. From: Downregulation of the calcium current in human right atrial myocytes from patients in sinus rhythm but with a high risk of atrial fibrillation Eur Heart J. 2008;29(9):1190-1197. doi:10.1093/eurheartj/ehn140 Eur Heart J | Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2008. For permissions please email: journals.permissions@oxfordjournals.org

Figure 3 The density of I<sub>CaL</sub> is homogeneous within a given sample. (A) The degree of identity between two I<sub>CaL</sub> values recorded in myocytes isolated from the same sample is provided by plotting the difference between measures against their mean; the bias (mean difference ± SD) is indicated by lines. (B) Correlation between I<sub>CaL</sub> measured from the same sample. From: Downregulation of the calcium current in human right atrial myocytes from patients in sinus rhythm but with a high risk of atrial fibrillation Eur Heart J. 2008;29(9):1190-1197. doi:10.1093/eurheartj/ehn140 Eur Heart J | Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2008. For permissions please email: journals.permissions@oxfordjournals.org

Figure 4 Density of peak I<sub>CaL</sub> as a function of clinical parameters. MVD, mitral valve disease; EF, left ventricle ejection fraction; n, the number of patients; values are mean ± SEM. From: Downregulation of the calcium current in human right atrial myocytes from patients in sinus rhythm but with a high risk of atrial fibrillation Eur Heart J. 2008;29(9):1190-1197. doi:10.1093/eurheartj/ehn140 Eur Heart J | Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2008. For permissions please email: journals.permissions@oxfordjournals.org

Figure 5 The effect of the β-adrenergic agonist isoproterenol on I<sub>CaL</sub> depends on current density. (A) Traces of I<sub>CaL</sub> (300 ms test pulse from −80 mV to 0 mV) recorded in control conditions (open circle) and at the steady-state effect of 1 µM isoproterenol (solid circle, ISO) in myocytes showing a normal (left panel) or enhanced (right panel) response to isoproterenol. (B) Relation between percentage of increase in I<sub>CaL</sub> upon 1 µM isoproterenol exposure and the peak I<sub>CaL</sub> density measured just before the application of isoproterenol. (C) Concentration-dependent effect of isoproterenol on I<sub>Ca</sub> recorded in patients with mitral valve disease or heart failure (solid circle) (n = 5) vs. patients with coronary artery disease and normal left ventricular function (open circle) (n = 5). (D) Percentage of increase in I<sub>CaL</sub> upon application of 10 M of the phosphodiesterase inhibitor, IBMX. From: Downregulation of the calcium current in human right atrial myocytes from patients in sinus rhythm but with a high risk of atrial fibrillation Eur Heart J. 2008;29(9):1190-1197. doi:10.1093/eurheartj/ehn140 Eur Heart J | Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2008. For permissions please email: journals.permissions@oxfordjournals.org