Figure 1 Hourglass metaphor for the development of complex diseases, with gene–gene and gene–environment interaction From: Dissecting complex disease:

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Figure 1 Hourglass metaphor for the development of complex diseases, with gene–gene and gene–environment interaction From: Dissecting complex disease: the quest for the Philosopher's Stone? Int J Epidemiol. 2006;35(3):562-571. doi:10.1093/ije/dyl001 Int J Epidemiol | Published by Oxford University Press on behalf of the International Epidemiological Association © The Author 2006; all rights reserved.

Figure 2 Heart attack risk calculator based on Framingham Heart Study data<sup>30</sup> From: Dissecting complex disease: the quest for the Philosopher's Stone? Int J Epidemiol. 2006;35(3):562-571. doi:10.1093/ije/dyl001 Int J Epidemiol | Published by Oxford University Press on behalf of the International Epidemiological Association © The Author 2006; all rights reserved.