Development of immunologic memory against tetanus toxoid and pertactin antigens from the diphtheria-tetanus-pertussis vaccine in atopic versus nonatopic.

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Presentation transcript:

Development of immunologic memory against tetanus toxoid and pertactin antigens from the diphtheria-tetanus-pertussis vaccine in atopic versus nonatopic children Patrick G. Holt, DSc, Anna Rudin, PhD, Claudia Macaubas, PhD, Barbara J. Holt, BSc, Julie Rowe, PhD, Richard Loh, FRACP, Peter D. Sly, FRACP Journal of Allergy and Clinical Immunology Volume 105, Issue 6, Pages 1117-1122 (June 2000) DOI: 10.1067/mai.2000.105804 Copyright © 2000 Mosby, Inc. Terms and Conditions

Fig. 1 Cytokine responses to mitogen and allergen in PBMCs from 6-year-old children. PBMCs were stimulated with either HDM (top) or PHA (bottom) as detailed in Methods, and culture supernatants were harvested at 48 hours for ELISAs. Data shown are group means ± SE. Journal of Allergy and Clinical Immunology 2000 105, 1117-1122DOI: (10.1067/mai.2000.105804) Copyright © 2000 Mosby, Inc. Terms and Conditions

Fig. 2 Vaccine antigen-specific IgG antibody in serum. Antibody levels were determined as detailed in Methods. Data shown are group means ± SE. Journal of Allergy and Clinical Immunology 2000 105, 1117-1122DOI: (10.1067/mai.2000.105804) Copyright © 2000 Mosby, Inc. Terms and Conditions

Fig. 3 Cytokine responses to tetanus toxoid antigen in PBMCs from 6-year-old children. PBMCs were stimulated with tetanus toxoid antigen, and ensuing cytokine responses were determined as cytokine protein (by ELISA) or cytokine-specific mRNA relative to mRNA specific for the housekeeping gene β-actin (by semiquantitative RT-PCR), as detailed in Methods. Data shown are group means ± SE. Journal of Allergy and Clinical Immunology 2000 105, 1117-1122DOI: (10.1067/mai.2000.105804) Copyright © 2000 Mosby, Inc. Terms and Conditions