A NOVEL NEUROIMAGING APPROACH TO CAPTURE COGNITIVE RESERVE Anita C. van Loenhoud, Alle Meije Wink, Colin Groot, Sander C.J. Verfaillie, Frederik Barkhof, Bart N.M. van Berckel, Philip Scheltens, Wiesje M. van der Flier, Rik Ossenkoppele  Alzheimer's & Dementia: The Journal of the Alzheimer's Association  Volume 12, Issue 7, Pages P74-P75 (July 2016) DOI: 10.1016/j.jalz.2016.06.126 Copyright © 2016 Terms and Conditions

Figure 1 Mean W-score in the whole-brain (green bars) and temporoparietal (blue bars) mask for the total sample, across three levels of education (i.e. low [1 to 3]; intermediate [4 and 5]; high [6 and 7]). Alzheimer's & Dementia: The Journal of the Alzheimer's Association 2016 12, P74-P75DOI: (10.1016/j.jalz.2016.06.126) Copyright © 2016 Terms and Conditions

Figure 2 W-scores in each gray matter voxel in the total sample for patients with low (left), intermediate (middle) and high (right) educational levels. Low CR is reflected by positive W- scores, high CR by negative W-scores. Alzheimer's & Dementia: The Journal of the Alzheimer's Association 2016 12, P74-P75DOI: (10.1016/j.jalz.2016.06.126) Copyright © 2016 Terms and Conditions

Figure 3 Brain regions showing a negative relationship (in neurological convention) between W-scores and education (p<.05, corrected for multiple comparisons using threshold-free cluster enhancement), adjusted for clinical severity (i.e. demented vs. non-demented). This indicates that, across different stages of the AD spectrum, highly educated patients could tolerate more atrophy (i.e. lower GM volumes) while maintaining cognitive function than patients with lower education. W-scores were generated based on a voxel-wise regression with MMSE as a predictor for gray matter volume, adjusted for age, sex, total intracranial volume and scanner type. Alzheimer's & Dementia: The Journal of the Alzheimer's Association 2016 12, P74-P75DOI: (10.1016/j.jalz.2016.06.126) Copyright © 2016 Terms and Conditions