From: Postoperative Use of Bevacizumab as an Antifibrotic Agent in Glaucoma Filtration Surgery in the Rabbit Invest. Ophthalmol. Vis. Sci.. 2009;50(7):3233-3237.

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From: Postoperative Use of Bevacizumab as an Antifibrotic Agent in Glaucoma Filtration Surgery in the Rabbit Invest. Ophthalmol. Vis. Sci.. 2009;50(7):3233-3237. doi:10.1167/iovs.08-2441 Figure Legend: Histologic characteristics of the surgical site associated with the control group (A, D, G) and the 5-FU group (B, E, H) in comparison with the bevacizumab group (C, F, I) at PD10. (A–C) Hematoxylin and eosin stain for evaluation of general histologic observation and total cellularity. Compare the large, elevated, loosely architectured bleb in the bevacizumab-treated group (C) with the flatter and more densely packed blebs in the control (A) and 5-FU (B) groups. Note the overall reduction in cellular infiltration of the sclera and conjunctiva (conj) in the bevacizumab group compared with the control and 5-FU groups. (D–F) Masson-Trichrome stain to evaluate the level of collagen deposition and fibrosis. Note the increased level of collagen deposition (fibrosis) in the blebs associated with the control (D) and 5-FU (E) groups compared with the (F) bevacizumab-treated group. (G–I) PCNA immunohistochemistry was used to assess the level of recent cell division/mitotic activity in the tissue. PCNA-positive/expressive cells stain red (arrow). The number of positively stained cells per four high-powered fields was graded. Bevacizumab-treated eyes (I) demonstrated a reduction in the number of PCNA-expressing cells compared with (G) control and (H) 5-FU eyes. Date of download: 11/4/2017 The Association for Research in Vision and Ophthalmology Copyright © 2017. All rights reserved.