Volume 77, Issue 4, Pages 473-477 (April 1980) Chronic Obstructive Pulmonary Disease following Idiopathic Pulmonary Fibrosis  D.S. McCarthy, M.D., D.N. Ostrow, M.D., F.C.C.P., E.S. Hershfield, M.D., F.C.C.P.  CHEST  Volume 77, Issue 4, Pages 473-477 (April 1980) DOI: 10.1378/chest.77.4.473 Copyright © 1980 The American College of Chest Physicians Terms and Conditions

Figure 1 Lung biopsy material from patient no 1. A, upper: Pronounced thickening of the alveolar walls and epithelial hyperplasia. There are numerous foamy macrophages free within the alveolar spaces (Hematoxylin and eosin stain; original magnification × 250). B, lower: Respiratory bronchiole demonstrating peribronchiolar inflammation and obliterative bronchiolitis (Hematoxylin and eosin stain; original magnification × 100). CHEST 1980 77, 473-477DOI: (10.1378/chest.77.4.473) Copyright © 1980 The American College of Chest Physicians Terms and Conditions

Figure 2 Radiologic film of Case 2. At the initial presentation there was diffuse infiltration and some loss of volume of the right lung, especially the lower half. Some infiltration is also present in the left lower zone. CHEST 1980 77, 473-477DOI: (10.1378/chest.77.4.473) Copyright © 1980 The American College of Chest Physicians Terms and Conditions

Figure 3 The relationship of lung volume in percentage of total lung capacity (TLC) to static transpulmonary pressure (PST) in two patients. Mean ± 1 SD values of normal subjects are shown for comparison (…). Patient 1…, patient 2…, ○ initial presentation, □ one month later, ▪ 7-12 months later. CHEST 1980 77, 473-477DOI: (10.1378/chest.77.4.473) Copyright © 1980 The American College of Chest Physicians Terms and Conditions

Figure 4 The relationship of maximal expiratory flow (Vmax) to static recoil pressure of the lungs (Pst) in the two patients. Mean ± 1 SD values of normal subjects are shown for comparison (…) at 50, 70 and 90 percent of TLC predicted. Patient 1…, patient 2…, ○ initial presentation, □ one month later, ▪ 7-12 months later. CHEST 1980 77, 473-477DOI: (10.1378/chest.77.4.473) Copyright © 1980 The American College of Chest Physicians Terms and Conditions