Figure 1 Morphine concentration plot by group and time from pilot study. IN = intranasal; IV = intravenous. From: Analgesic Efficacy and Safety of Morphine-Chitosan.

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Figure 1 Morphine concentration plot by group and time from pilot study. IN = intranasal; IV = intravenous. From: Analgesic Efficacy and Safety of Morphine-Chitosan Nasal Solution in Patients with Moderate to Severe Pain Following Orthopedic Surgery Pain Med. 2007;9(1):3-12. doi:10.1111/j.1526-4637.2007.00300.x Pain Med | American Academy of Pain Medicine

Figure 2 Patient flow diagram Figure 2 Patient flow diagram. This schematic illustrates the study design for patient randomization, treatment, and patient disposition during the study. IN = intranasal; IV = intravenous. From: Analgesic Efficacy and Safety of Morphine-Chitosan Nasal Solution in Patients with Moderate to Severe Pain Following Orthopedic Surgery Pain Med. 2007;9(1):3-12. doi:10.1111/j.1526-4637.2007.00300.x Pain Med | American Academy of Pain Medicine

Figure 3 Total pain relief through 4 hours (TOTPAR4) based upon 100 mm visual analog scale (VAS) pain relief assessments for placebo, four dosage levels of intranasal (IN) morphine, and intravenous (IV) morphine. Values shown are mean and SD for the intent to treat population, in which missing data points are taken as the last observation carried forward. From: Analgesic Efficacy and Safety of Morphine-Chitosan Nasal Solution in Patients with Moderate to Severe Pain Following Orthopedic Surgery Pain Med. 2007;9(1):3-12. doi:10.1111/j.1526-4637.2007.00300.x Pain Med | American Academy of Pain Medicine

Figure 4 Pain intensity difference plot by group and time (4 hours) Figure 4 Pain intensity difference plot by group and time (4 hours). PID = pain intensity difference; LOCF = last observation carried forward; IN = intranasal; IV = intravenous. From: Analgesic Efficacy and Safety of Morphine-Chitosan Nasal Solution in Patients with Moderate to Severe Pain Following Orthopedic Surgery Pain Med. 2007;9(1):3-12. doi:10.1111/j.1526-4637.2007.00300.x Pain Med | American Academy of Pain Medicine

Figure 5 Pain relief plot by group and time (4 hours) Figure 5 Pain relief plot by group and time (4 hours). IN = intranasal; IV = intravenous; VAS = visual analog scale. From: Analgesic Efficacy and Safety of Morphine-Chitosan Nasal Solution in Patients with Moderate to Severe Pain Following Orthopedic Surgery Pain Med. 2007;9(1):3-12. doi:10.1111/j.1526-4637.2007.00300.x Pain Med | American Academy of Pain Medicine