Self-assembly of Peptide Nanotubes NSF Site Visit June 10, 2004 Shuguang Zhang Center for Biomedical Engineering, Center for Bits & Atoms Massachusetts Institute of Technology Cambridge, MA 02139, USA http://web.mit.edu/lms/www/

Peptide surfactant-detergents http://web.mit.edu/lms/www/

Steve Santoso, NanoLetters, 7/2002 Sylvain Vauthey, PNAS, 4/2002, Steve Santoso, NanoLetters, 7/2002 Geoffrey von Maltzahn, Langmuir, 5/2003 http://web.mit.edu/lms/www/

+ lipid bilayer solubilized membrane proteins detergent micelles + monomers + lipid-detergent micelles http://web.mit.edu/lms/www/

The energy harvest systems are embedded in membranes http://web.mit.edu/lms/www/

Peptide detergents stabilized photosystem I for long-term 650 675 700 725 750 775 800 0.0 0.2 0.4 0.6 0.8 1.0 Fluorescent intensity [a.u.] Wavelength (l) [nm] diluted solution A6K day 7 day 21 670 690 1 l [nm] h [a.u.] Absorption [a.u.] Das, et al., NanoLetters, June 2004 http://web.mit.edu/lms/www/

Das, et al., NanoLetters, June 2004 Peptide detergents stabilized photosystem I generate current & voltage 700 750 800 850 900 950 0.0 0.2 0.4 0.6 0.8 1.0 Quantum efficiency [a.u.] Wavelength [nm] Absorption [a.u.] -0.05 0.05 -0.4 -0.2 J [mA/cm2] V [V] dark light w. peptides light - no peptides (l = 808nm, 10 W/cm2) Das, et al., NanoLetters, June 2004 http://web.mit.edu/lms/www/