Representative 10-s EEG recordings from GAERS: during baseline (prior to injection of any drug) (i), following the i.c.v. injection of 4 μl of vehicle.

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1 Mechanism of Action Greg Beatch, Ph.D. Vice President, Scientific Affairs Cardiome Pharma Corp.

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Presentation transcript:

Representative 10-s EEG recordings from GAERS: during baseline (prior to injection of any drug) (i), following the i.c.v. injection of 4 μl of vehicle (40% propylene glycol, 10% ethanol, and 50% saline) (ii), and following the injection of 15 μg of CBZ in 4 μl of vehicle (iii). Representative 10-s EEG recordings from GAERS: during baseline (prior to injection of any drug) (i), following the i.c.v. injection of 4 μl of vehicle (40% propylene glycol, 10% ethanol, and 50% saline) (ii), and following the injection of 15 μg of CBZ in 4 μl of vehicle (iii). The vehicle had no effect on baseline EEG recording nor the number, duration, or morphology of the SWDs. CBZ prolonged the total time in seizure over the 90-min postinjection EEG recording. Lige Liu et al. J Pharmacol Exp Ther 2006;319:790-798 The American Society for Pharmacology and Experimental Therapeutics