Skin barrier abnormality caused by filaggrin (FLG) mutations is associated with increased serum 25-hydroxyvitamin D concentrations  Jacob P. Thyssen, MD, Betina Thuesen, PhD, Cornelia Huth, PhD, Marie Standl, MSc, Charlotte G. Carson, MD, Joachim Heinrich, PhD, Ursula Krämer, MD, Jürgen Kratzsch, MD, Nikolaj D. Berg, PhD, Torkil Menné, MD, Jeanne D. Johansen, MD, Berit C. Carlsen, MD, Sigrid Schwab, MSc, Barbara Thorand, PhD, Marianne Munk, BA, Henri Wallaschofski, MD, Lene Heickendorff, MD, Michael Meldgaard, PhD, Pal B. Szecsi, MD, Steen Stender, MD, Klaus Bønnelykke, MD, Stephan Weidinger, MD, Hans Bisgaard, MD, Allan Linneberg, MD  Journal of Allergy and Clinical Immunology  Volume 130, Issue 5, Pages 1204-1207.e2 (November 2012) DOI: 10.1016/j.jaci.2012.06.046 Copyright © 2012 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 1 Forest plot illustrating the study-specific and combined differences in geometric means of serum 25-OH vitamin D concentrations in percentages between FLG mutation (R501X, 2282del4, or both) and nonmutation carriers adjusted for age, sex, body mass index, AD, supplementary vitamin D intake, and time of year of vitamin D testing. Journal of Allergy and Clinical Immunology 2012 130, 1204-1207.e2DOI: (10.1016/j.jaci.2012.06.046) Copyright © 2012 American Academy of Allergy, Asthma & Immunology Terms and Conditions