From: Wnt/β-Catenin Signaling Mediates Regeneration of Retinal Pigment Epithelium After Laser Photocoagulation in Mouse Eye Invest. Ophthalmol. Vis. Sci..

Slides:

Advertisements

Similar presentations

Invest. Ophthalmol. Vis. Sci ;47(1): doi: /iovs Figure Legend:

Advertisements

From: Increased Choroidal Neovascularization following Laser Induction in Mice Lacking Lysyl Oxidase-like 1 Invest. Ophthalmol. Vis. Sci ;49(6):

From: Acetylation Preserves Retinal Ganglion Cell Structure and Function in a Chronic Model of Ocular Hypertension Invest. Ophthalmol. Vis. Sci ;55(11):

Invest. Ophthalmol. Vis. Sci ;56(8): doi: /iovs Figure Legend:

From: Reliability of the Mouse Model of Choroidal Neovascularization Induced by Laser Photocoagulation Invest. Ophthalmol. Vis. Sci ;55(10):

From: Molecular Mechanisms Underlying the Filtration Bleb-Maintaining Effects of Suberoylanilide Hydroxamic Acid (SAHA) Invest. Ophthalmol. Vis. Sci..

From: Inhibition of T-Cell Activation by Retinal Pigment Epithelial Cells Derived From Induced Pluripotent Stem Cells Invest. Ophthalmol. Vis. Sci ;56(2):

Figure Legend: From: B-RAF signaling promotes optic nerve regeneration

From: Aldose Reductase Mediates Transforming Growth Factor β2 (TGF-β2)–Induced Migration and Epithelial-To-Mesenchymal Transition of Lens-Derived Epithelial.

From: Downregulation of PTEN at Corneal Wound Sites Accelerates Wound Healing through Increased Cell Migration Invest. Ophthalmol. Vis. Sci ;52(5):

Invest. Ophthalmol. Vis. Sci ;52(1): doi: /iovs Figure Legend:

Invest. Ophthalmol. Vis. Sci ;52(13): doi: /iovs Figure Legend:

From: Topical Pazopanib Blocks VEGF-Induced Vascular Leakage and Neovascularization in the Mouse Retina but Is Ineffective in the Rabbit Invest. Ophthalmol.

Invest. Ophthalmol. Vis. Sci ;45(6): doi: /iovs Figure Legend:

From: Systemic and Intravitreal Delivery of Dendrimers to Activated Microglia/Macrophage in Ischemia/Reperfusion Mouse Retina Invest. Ophthalmol. Vis.

From: Lectin from Agaricus bisporus Inhibited S Phase Cell Population and Akt Phosphorylation in Human RPE Cells Invest. Ophthalmol. Vis. Sci ;53(12):

From: Targeted Administration into the Suprachoroidal Space Using a Microneedle for Drug Delivery to the Posterior Segment of the Eye Invest. Ophthalmol.

From: Experimental Anterior Ischemic Optic Neuropathy in Diabetic Mice Exhibited Severe Retinal Swelling Associated With VEGF Elevation Invest. Ophthalmol.

From: The Use of Autologous Serum in the Development of Corneal and Oral Epithelial Equivalents in Patients with Stevens-Johnson Syndrome Invest. Ophthalmol.

From: Analysis of Kinesin-2 Function in Photoreceptor Cells Using Synchronous Cre-loxP Knockout of Kif3a with RHO-Cre Invest. Ophthalmol. Vis. Sci ;47(11):

From: A Murine Model for Retinopathy of Prematurity Identifies Endothelial Cell Proliferation as a Potential Mechanism for Plus Disease Invest. Ophthalmol.

Invest. Ophthalmol. Vis. Sci ;54(2): doi: /iovs Figure Legend:

Invest. Ophthalmol. Vis. Sci ;52(5): doi: /iovs Figure Legend:

From: Klf4 Regulates the Expression of Slurp1, Which Functions as an Immunomodulatory Peptide in the Mouse Cornea Invest. Ophthalmol. Vis. Sci ;53(13):

From: Elevated Expression of O-GlcNAc–Modified Proteins and O-GlcNAc Transferase in Corneas of Diabetic Goto-Kakizaki Rats Invest. Ophthalmol. Vis. Sci..

Invest. Ophthalmol. Vis. Sci ;57(8): doi: /iovs Figure Legend:

From: Inflammatory Mediators Induced by Amyloid-Beta in the Retina and RPE In Vivo: Implications for Inflammasome Activation in Age-Related Macular Degeneration.

From: Deficiency of SHP-1 Protein-Tyrosine Phosphatase in “Viable Motheaten” Mice Results in Retinal Degeneration Invest. Ophthalmol. Vis. Sci ;47(3):

From: Systemic Treatment With Glutathione PEGylated Liposomal Methylprednisolone (2B3-201) Improves Therapeutic Efficacy in a Model of Ocular Inflammation.

From: Fundus Camera-Delivered Light-Induced Retinal Degeneration in Mice With the RPE65 Leu450Met Variant is Associated With Oxidative Stress and Apoptosis.

From: High Glucose Induces Mitochondrial Dysfunction in Retinal Müller Cells: Implications for Diabetic Retinopathy Invest. Ophthalmol. Vis. Sci ;58(7):

Invest. Ophthalmol. Vis. Sci ;50(11): doi: /iovs Figure Legend:

From: Prostaglandin Analogues and Mouse Intraocular Pressure: Effects of Tafluprost, Latanoprost, Travoprost, and Unoprostone, Considering 24-Hour Variation.

From: Anti-Inflammatory and Antioxidative Effects of Camellia japonica on Human Corneal Epithelial Cells and Experimental Dry Eye: In Vivo and In Vitro.

From: Enhancement of rAAV2-Mediated Transgene Expression in Retina Cells In Vitro and In Vivo by Coadministration of Low-Dose Chemotherapeutic Drugs Invest.

Invest. Ophthalmol. Vis. Sci ;58(9): doi: /iovs Figure Legend:

From: Hypoxic-Preconditioned Bone Marrow Stem Cell Medium Significantly Improves Outcome After Retinal Ischemia in Rats Invest. Ophthalmol. Vis. Sci..

From: Optical Coherence Tomography Angiography in Mice: Comparison with Confocal Scanning Laser Microscopy and Fluorescein Angiography Trans. Vis. Sci.

From: Effect of Hyaluronic Acid on Intraocular Pressure in Rats

From: Role of Caveolin-1 for Blocking the Epithelial-Mesenchymal Transition in Proliferative Vitreoretinopathy Invest. Ophthalmol. Vis. Sci ;58(1):

From: Changes in the Photoreceptor Mosaic of P23H-1 Rats During Retinal Degeneration: Implications for Rod-Cone Dependent Survival Invest. Ophthalmol.

From: Serum Deprivation Induces Apoptotic Cell Death of Transformed Rat Retinal Ganglion Cells via Mitochondrial Signaling Pathways Invest. Ophthalmol.

Invest. Ophthalmol. Vis. Sci ;52(8): doi: /iovs Figure Legend:

Invest. Ophthalmol. Vis. Sci ;51(9): doi: /iovs Figure Legend:

Invest. Ophthalmol. Vis. Sci ;55(12): doi: /iovs Figure Legend:

From: CD11b+GR1+ Myeloid Cells Secrete NGF and Promote Trigeminal Ganglion Neurite Growth: Implications for Corneal Nerve Regeneration Invest. Ophthalmol.

From: Canonical/β-Catenin Wnt Pathway Activation Improves Retinal Pigmented Epithelium Derivation From Human Embryonic Stem Cells Invest. Ophthalmol. Vis.

From: Canonical/β-Catenin Wnt Pathway Activation Improves Retinal Pigmented Epithelium Derivation From Human Embryonic Stem Cells Invest. Ophthalmol. Vis.

From: An Experimental Protocol of the Model to Quantify Traction Applied to the Retina by Vitreous Cutters Invest. Ophthalmol. Vis. Sci ;51(8):

From: Reduced Retina Microglial Activation and Improved Optic Nerve Integrity with Minocycline Treatment in the DBA/2J Mouse Model of Glaucoma Invest.

From: Noninvasive and Simultaneous Imaging of Layer-Specific Retinal Functional Adaptation by Manganese-Enhanced MRI Invest. Ophthalmol. Vis. Sci ;47(6):

From: Adenovirus Type 37 Keratitis in the C57BL/6J Mouse

Invest. Ophthalmol. Vis. Sci ;56(12): doi: /iovs Figure Legend:

From: NKT Cell Exacerbation of Liver Metastases Arising from Melanomas Transplanted into Either the Eyes or Spleens of Mice Invest. Ophthalmol. Vis. Sci..

From: Alterations in Protein Expression in Tree Shrew Sclera during Development of Lens-Induced Myopia and Recovery Invest. Ophthalmol. Vis. Sci ;53(1):

Invest. Ophthalmol. Vis. Sci ;57(6): doi: /iovs Figure Legend:

From: Mesenchymal Stem Cells Ameliorate Experimental Autoimmune Uveoretinitis by Comprehensive Modulation of Systemic Autoimmunity Invest. Ophthalmol.

From: Cross Talk between c-Met and Epidermal Growth Factor Receptor during Retinal Pigment Epithelial Wound Healing Invest. Ophthalmol. Vis. Sci ;48(5):

From: VEGF Antagonists Decrease Barrier Function of Retinal Pigment Epithelium In Vitro: Possible Participation of Intracellular Glutathione Invest. Ophthalmol.

Invest. Ophthalmol. Vis. Sci ;58(2): doi: /iovs Figure Legend:

Invest. Ophthalmol. Vis. Sci ;50(4): doi: /iovs Figure Legend:

From: Silencing of the CHM Gene Alters Phagocytic and Secretory Pathways in the Retinal Pigment Epithelium Invest. Ophthalmol. Vis. Sci ;51(2):

From: Diffusion Tensor Imaging Detected Optic Nerve Injury Correlates with Decreased Compound Action Potentials after Murine Retinal Ischemia Invest. Ophthalmol.

Invest. Ophthalmol. Vis. Sci ;58(7): doi: /iovs Figure Legend:

From: β-Catenin/CBP–Dependent Signaling Regulates TGF-β–Induced Epithelial to Mesenchymal Transition of Lens Epithelial Cells Invest. Ophthalmol. Vis.

From: Fate Maps of Neural Crest and Mesoderm in the Mammalian Eye

From: Fate Maps of Neural Crest and Mesoderm in the Mammalian Eye

From: Pressure-Induced Regulation of IL-6 in Retinal Glial Cells: Involvement of the Ubiquitin/Proteasome Pathway and NFκB Invest. Ophthalmol. Vis. Sci..

From: Scanning Laser Polarimetry with Variable Corneal Compensation: Identification and Correction for Corneal Birefringence in Eyes with Macular Disease.

Invest. Ophthalmol. Vis. Sci ;55(7): doi: /iovs Figure Legend:

Presentation transcript:

From: Wnt/β-Catenin Signaling Mediates Regeneration of Retinal Pigment Epithelium After Laser Photocoagulation in Mouse Eye Invest. Ophthalmol. Vis. Sci.. 2015;56(13):8314-8324. doi:10.1167/iovs.15-18359 Figure Legend: Representative confocal micrographs from whole-mount preparations 7 days after laser photocoagulation, immunostained with molecular markers of EMT (vimentin, green; α-SMA, red). (A, F) Expression of vimentin and α-SMA was not detected in the control RPE. (B1, G1) Expression levels of vimentin and α-SMA were higher in the laser-treated RPE than in the control RPE on day 7 after laser photocoagulation. (B2, B3, G2, G3) Many EdU-positive cells in the laser-treated area colocalized with vimentin and α-SMA expression. (C, H) Treatment of laser-treated RPE with vehicle increased the expression levels of vimentin and α-SMA. (D, I) Dkk-1 decreased the expression levels of vimentin and α-SMA compared to vehicle-injected RPE. (E, J) Mean fluorescence intensity calculated using ImageJ for vimentin and α-SMA. Quantifying relative fluorescence intensity showed significantly increased intensity in the laser-treated group versus the control group. The Dkk-1-injected group showed lower intensity than the vehicle-injected group (mean ± SD, n = 3 mice per group, *P < 0.05). Scale bars: 100 μm. Date of download: 11/5/2017 The Association for Research in Vision and Ophthalmology Copyright © 2017. All rights reserved.