The Research Question Use of Antidepressants in Patients with Depression and Cardiometabolic Disease Bhautesh Jani, David Purves, Sarah Barry, Colin McCowan,

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Presentation transcript:

The Research Question Use of Antidepressants in Patients with Depression and Cardiometabolic Disease Bhautesh Jani, David Purves, Sarah Barry, Colin McCowan, Jonathan Cavanagh, Frances Mair Do antidepressants work in the long run in treatment of depressive symptoms in patients with cardiometabolic diseases? Why this is important? Depression is very common in Cardiometabolic disease (CHD, Diabetes, Stroke) Depression increases the risk of complications- deaths, vascular events, compliance, quality of life BP34 Adherence to Antibiotic Prescribing for LRTI and Association With Recovery (Oral Presentation On Completed Research) Nick Francis, MD, PhD, Cardiff University; David Gillespie; Jacqueline Nuttall; Paul Little; Theo Verheij; Samuel Coenen; Jochen Cals; Kerenza Hood; Herman Goossens; Christopher Butler

What the Researchers Did Method- retrospective cohort review of data in routine practice N=7080 patients with cardiometabolic disease had HADS-D (Hospital Anxiety and Depression Scale) at baseline and 12 months follow-up Compared mean change in HADS-D for antidepressants prescribed vs. untreated Compared rate of remission (HADS-D>8)

What the Researchers Found Mean change in HADS-D at 12 months (Efficacy) No difference between untreated and continuously treated group Intermittently treated group did worse than untreated group Rate of remission at 12 months(Effectiveness) No difference in odds of remission between untreated and continuously treated group Intermittently treated group had lower odds of remission aged ≥18 years, consulting with an illness where an acute or worsened cough was the main or dominant symptom, or had a clinical presentation that suggested a lower respiratory tract infection that had been present for ≥28 days.

What This Means for Clinical Practice No significant improvement in follow-up HADS-D or in odds of remission at 12 months with antidepressants Baseline HADS-D severity did not change the trend in results The role of antidepressants in treatment of depression in cardiometabolic disease needs further scrutiny