Cementation in the age of digital dentistry. A review of the literature. Hadzhigaev, Viktor1; Zlatev, Stefan1; Vlahova, Angelina2; Todorov, Georgi3. 1 Assistant Professor, Department of Prosthetic Dental Medicine, Faculty of dental medicine, Medical University Plovdiv 2 Associate Professor, Department of Prosthetic Dental Medicine, Faculty of dental medicine, Medical University Plovdiv 3 Professor, Department of Prosthetic Dental Medicine, Faculty of dental medicine, Medical University Plovdiv Introduction: Cementation is the final stage in clinical cases restored with FPD’s. Since the introduction of CAD/CAM technology a rapid increase in the usage of constructions based on zirconium dioxide is observed. This material and its modifications may require a different cementation protocol. Materials and Method: A literature search concerning cementation of ZrO2 based FPD’s manufactured using CAD/CAM technology was conducted in the PubMed (US national library of medicine) database and Elsevier’s search engine for scientific literature - ScienceDirect. A combination of key words and Mesh terms were used with the Boolean operators: “OR”, “AND” and “NOT”. Language restriction to articles in English and a time filter for researches conducted during the last 5 years were applied. Results and discussion: The search yielded 268 results. After a complex study selection protocol, 42 articles relevant to the topic were chosen. The papers were divided by their type – “in vitro” and “in vivo”. The results of the studies were organized in different sections according to their main topic. Type of publication Count In vitro 35 Fracture strength 8 Marginal fit 10 Micro-leakage 5 Bond strength 12 In vivo 7 Prospective; survival 3 Prospective; USPHS criteria 4 Total 42 Purpose: The aim of the current review of the literature is to organize the current knowledge regarding the cementation of ZrO2 based FPD’s manufactured utilizing the CAD/CAM technology. Identified articles(n=268) Removal of duplicates (n=79) Included for title and abstract analysis(n=189) Excluded titles (n=65) Excluded based on specific criteria (n=79) Included for Full text analysis (n=42) Conclusion: The identified articles differ in their methodology and purpose, thereby it is not possible to conduct a meta-analysis of the reported results. In conclusion, there is no universal protocol for luting of CAD/CAM fabricated restorations but a preference towards composite cements is observed, when there isn’t sufficient macro-mechanical retention.