Autoimmune disease, such as autoimmune thyroiditis, and malignancy are extremely rare causes. In the child with chronic urticaria, it is often difficult or impossible to identify a single cause. In these patients, one attempts to control the development of new lesions with a daily schedule of nonsedating antihistamines. Source: Urticarial, Purpuric, and Vascular Reactions, Weinberg's Color Atlas of Pediatric Dermatology, 5e Citation: Prose NS, Kristal L. Weinberg's Color Atlas of Pediatric Dermatology, 5e; 2017 Available at: http://accesspediatrics.mhmedical.com/DownloadImage.aspx?image=/data/books/1913/weinderm5_ch16_f004.png&sec=138562782&BookID=1913&ChapterSecID=138562777&imagename= Accessed: November 06, 2017 Copyright © 2017 McGraw-Hill Education. All rights reserved