The effect of short-term, high-dose oral N-acetylcysteine treatment on oxidative stress markers in cystic fibrosis patients with chronic P. aeruginosa.

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Presentation transcript:

The effect of short-term, high-dose oral N-acetylcysteine treatment on oxidative stress markers in cystic fibrosis patients with chronic P. aeruginosa infection — A pilot study Marianne Skov, Tacjana Pressler, Jens Lykkesfeldt, Henrik Enghusen Poulsen, Peter Østrup Jensen, Helle Krogh Johansen, Tavs Qvist, Dorthe Kræmer, Niels Høiby, Oana Ciofu Journal of Cystic Fibrosis Volume 14, Issue 2, Pages 211-218 (March 2015) DOI: 10.1016/j.jcf.2014.09.015 Copyright © 2014 European Cystic Fibrosis Society. Terms and Conditions

Fig. 1 Changes in the plasma levels of ascorbic acid (AA) and dehydroascorbate (DHA) at the end of the study compared to baseline in the NAC treated group (A and C) and in the control group (B and D, respectively). Significant higher plasma levels of ascorbate (p=0.037) and lower of oxidized ascorbate (p=0.004) compared to baseline were found in the NAC treated patients but not in the control group. Paired t-test was used to analyze the differences between the levels at the end of the study compared to baseline. Journal of Cystic Fibrosis 2015 14, 211-218DOI: (10.1016/j.jcf.2014.09.015) Copyright © 2014 European Cystic Fibrosis Society. Terms and Conditions