Age of onset, pattern of distribution, and histology of aneurysm development in a genetically predisposed mouse model Colleen M. Brophy, MD, Joan E.

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Presentation transcript:

Age of onset, pattern of distribution, and histology of aneurysm development in a genetically predisposed mouse model Colleen M. Brophy, MD, Joan E. Tilson, BS, Irwin M. Braverman, MD, M.David Tilson, MD Journal of Vascular Surgery Volume 8, Issue 1, Pages 45-48 (July 1988) DOI: 10.1016/0741-5214(88)90242-X Copyright © 1988 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions

Fig. 1 The natural history of aneurysm formation in the blotchy mouse is depicted in the computer-generated log curve. By 6 months of age all blotchy male mice had aneurysms. Journal of Vascular Surgery 1988 8, 45-48DOI: (10.1016/0741-5214(88)90242-X) Copyright © 1988 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions

Fig. 2 Iron hematoxylin staining of normal (A) and blotchy (B) aortas at low magnification in 21-day-old mice. Blotchy aorta is thicker and has a smaller diameter at this young age before aneurysm formation. Journal of Vascular Surgery 1988 8, 45-48DOI: (10.1016/0741-5214(88)90242-X) Copyright © 1988 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions

Fig. 3 At higher power the histologic differences between normal (A) and blotchy (B) aortas are better visualized. The blotchy aorta exhibits thickened lamellar spaces containing pleomorphic smooth muscle cells (S). Lumen (L) is lined with endothelial cells (E). Journal of Vascular Surgery 1988 8, 45-48DOI: (10.1016/0741-5214(88)90242-X) Copyright © 1988 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions

Fig. 4 Transmission electron micrographs (original magnification × 5000) of normal (A) and blotchy (B) aortas with the lumen (L) in the upper left corner. Elastic lamellae (E) are wavy with areas of vacuolization in aorta of the blotchy mouse. Smooth muscle cells (S) appear pleomorphic. Projections of elastic fibers (Ep) are present. Journal of Vascular Surgery 1988 8, 45-48DOI: (10.1016/0741-5214(88)90242-X) Copyright © 1988 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions

Fig. 5 At higher magnification ( × 15,000) the “lumpy-bumpy” projections of elastic fibers (Ep) into the interlamellar space are better visualized. E, elastic lamellae. Journal of Vascular Surgery 1988 8, 45-48DOI: (10.1016/0741-5214(88)90242-X) Copyright © 1988 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions