Stem cell-based therapy for malignant glioma

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Stem cell-based therapy for malignant glioma Daniel Bexell, Andreas Svensson, Johan Bengzon Cancer Treatment Reviews Volume 39, Issue 4, Pages 358-365 (June 2013) DOI: 10.1016/j.ctrv.2012.06.006 Copyright © 2012 Elsevier Ltd Terms and Conditions

Fig. 1 (A) Phase-contrast micrograph of immortalised human NSCs after being subjected to cell culture conditions supporting neuronal differentiation. Insert in (A) Human NSCs grown as free-floating spheres in cell culture medium stimulating proliferation. (B) Immunofluorescent photomicrograph of human NSCs (red) infiltrating a human glioma (green) implanted into the immunocompromised mouse brain. (C) Phase-contrast photomicrograph of human MSCs growing adherently on a plastic surface in vitro. (D) Rat MSCs (red) infiltrating an invasively growing rat glioma (green) in vivo. Scale bar: 60μm in A (250μm in inflicted neurosphere photograph), 150μm in B, 100μm in C, and 120μm in D. Fig. 1B is reproduced by permission of the publisher and the author.23 Cancer Treatment Reviews 2013 39, 358-365DOI: (10.1016/j.ctrv.2012.06.006) Copyright © 2012 Elsevier Ltd Terms and Conditions

Fig. 2 Schematic illustration of the major mechanisms contributing to tumour-selective tropism of grafted stem cells in glioblastoma. Cancer Treatment Reviews 2013 39, 358-365DOI: (10.1016/j.ctrv.2012.06.006) Copyright © 2012 Elsevier Ltd Terms and Conditions