From: Mitochondrial Dynamics Regulate Growth Cone Motility, Guidance, and Neurite Growth Rate in Perinatal Retinal Ganglion Cells In Vitro Invest. Ophthalmol.

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From: Mitochondrial Dynamics Regulate Growth Cone Motility, Guidance, and Neurite Growth Rate in Perinatal Retinal Ganglion Cells In Vitro Invest. Ophthalmol. Vis. Sci.. 2012;53(11):7402-7411. doi:10.1167/iovs.12-10298 Figure Legend: Overexpressing KLF4 and KLF6 differentially regulates mean mitochondrial area, density, and mtDNA replication. (a) Normalized to E20, E20 (black) and P5 (white) control (Cntrl.) RGC mitochondria detected with MitoTracker CMXROS had similar mean areas at similar densities. In contrast, KLF4 reduced the mean area in E20 and P5 RGCs, but not density at 1 DIV. KLF6 reduced the mean area in E20 and P5 RGCs to lower levels than KLF4. KLF6 also reduced the mean density in E20 and P5 RGCs. (b) mtDNA was detected by amplifying incorporated EdU with Click-IT-Oregon green followed by anti-Oregon green-HRP tyramide amplification (green), anti-β3-tubulin (red), GC. (c) KLF4 but not KLF6 reduced EdU incorporation in E20 (black) and P5 (white) RGCs. Error bars: SEM. Bar: 10 μm. n ≥ 30 neurites per condition, *P < 0.0001, **P < 0.05. Date of download: 11/6/2017 The Association for Research in Vision and Ophthalmology Copyright © 2017. All rights reserved.