From: Perineural Administration of Dexmedetomidine in Combination with Bupivacaine Enhances Sensory and Motor Blockade in Sciatic Nerve Block without Inducing.

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From: Perineural Administration of Dexmedetomidine in Combination with Bupivacaine Enhances Sensory and Motor Blockade in Sciatic Nerve Block without Inducing Neurotoxicity in Rat Anesthes. 2008;109(3):502-511. doi:10.1097/ALN.0b013e318182c26b Figure Legend: Fig. 1. Sensory blockade: Dexmedetomidine added to bupivacaine enhanced the duration of sensory blockade in response to lateral paw pinch when compared with bupivacaine alone. Bupivacaine and bupivacaine plus dexmedetomidine showed improved sensory scores when compared with saline and dexmedetomidine. The time course demonstrates the progression from complete sensory blockade (score = 3) to recovery of normal sensory function (score = 0). Time course data for sensory testing were analyzed using a nonparametric model with ordinal logistic regression for repeated measures and generalized estimating equations. * Significant differences for bupivacaine plus dexmedetomidine  versus  bupivacaine alone at specific times after injection. † Significant differences between dexmedetomidine and saline when compared with bupivacaine plus dexmedetomidine and bupivacaine.  Date of download: 11/6/2017 Copyright © 2017 American Society of Anesthesiologists. All rights reserved.

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