Age-associated changes in human hematopoietic stem cells

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Age-associated changes in human hematopoietic stem cells Wendy W. Pang, Stanley L. Schrier, Irving L. Weissman Seminars in Hematology Volume 54, Issue 1, Pages 39-42 (January 2017) DOI: 10.1053/j.seminhematol.2016.10.004 Copyright © 2017 Elsevier Inc. Terms and Conditions

Fig. 1 Schematic model of clonal changes in hematopoietic stem cell (HSC) population with aging. The quantity of HSCs increase with age, but the clonal diversity likely decreases with development of myeloid bias. In age-associated clonal hematopoietic diseases such as pre-leukemic conditions of myelodysplastic syndrome (MDS) and myeloproliferative disorders (MPDs), aberrant HSC clones, which have accumulated disease-causing mutations, dominate the HSC population. Seminars in Hematology 2017 54, 39-42DOI: (10.1053/j.seminhematol.2016.10.004) Copyright © 2017 Elsevier Inc. Terms and Conditions