Neural Basis of the Perception and Estimation of Time SE367 Homework 3

Previous works Scalar timing theory(Gibbon et al.1984) Neurophysiological model of timing(Matell & Meck 2004)

EVIDENCE FAVORING A COMMON TIMING MECHANISM Work started in late 19th century Time dependent and time independent sources Temporal processing

EVIDENCE FAVORING A UBIQUITOUS TIMING ABILITY OF CORTICAL NETWORKS Timing is an inherent computational ability of every cortical circuit Psychophysical experiments suggest that sensory timing is local.

AN INTERMEDIATE HYPOTHESIS Merchant and colleagues (2008c)

NEUROPHYSIOLOGICAL BASIS OF TIME ESTIMATION: RAMPING ACTIVITY IN THE CORE TIMING CIRCUIT Most studies report climbing activity during a variety of timing tasks.

NEUROANATOMICAL AND NEUROCHEMICAL SYSTEMS FOR INTERVAL TIMING The centrality of the striatum and dopamine (DA) neurotransmission in explicit timing. Frontoparietal systems may govern attention and working memory, which interact with timekeeping processes

FUNCTIONAL SIGNIFICANCE OF BRAIN CIRCUITS THAT GOVERN INTERVAL TIMING Pairwise subtractions of brain activation during time discrimination (T), pitch discrimination (P), and the sensorimotor control (C) tasks were conducted for each period.

ILLUSIONS OF TIME Emerging neuroimaging research suggests that the mechanisms may be partially context dependent.

CONCLUSIONS

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