Hormone-sensitive lipase activity (a) is expressed as nmol of free fatty acids released per min per mg of tissue protein. cAMP accumulation (b) is expressed.

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Hormone-sensitive lipase activity (a) is expressed as nmol of free fatty acids released per min per mg of tissue protein. cAMP accumulation (b) is expressed as nmol/mg of tissue protein. Control (untreated) and chronic ethanol drinking (CED) groups received saline or UK 14304 60 min prior to the assay. The results are shown as means ± SEM from 20–24 mice for lean groups, 16–20 for obese groups, and 8–10 mice for UK 14304-treated groups. ¶¶P < 0.01 chronic ethanol > control; **P < 0.01 UK 14304 versus control. EFFECTS OF ACUTE AND CHRONIC ETHANOL ADMINISTRATION ON THE RESPONSE OF MOUSE ADIPOSE TISSUE HORMONE-SENSITIVE LIPASE TO α2-ADRENOCEPTOR ACTIVATION BY UK 14304 Alcohol Alcohol. 2001;36(5):381-387. doi:10.1093/alcalc/36.5.381 Alcohol Alcohol | © 2001 Medical Council on Alcohol

Hormone-sensitive lipase activity (a) is expressed as nmol free fatty acids released per min per mg of tissue protein. cAMP accumulation (b) is expressed as nmol/mg of tissue protein. Acute ethanol treatment was a single dose of 2.5 g/kg i.p. 60 min prior to the assays. Chronic ethanol treatment consisted of 20% ethanol as sole drinking fluid for 4 weeks. The results are shown as means ± SEM from 20–24 mice for lean groups and 8–10 mice for obese groups. *P < 0.05, **P < 0.01 ethanol group < control; ¶P < 0.05, ethanol group > control; †P < 0.05, lean versus obese control. EFFECTS OF ACUTE AND CHRONIC ETHANOL ADMINISTRATION ON THE RESPONSE OF MOUSE ADIPOSE TISSUE HORMONE-SENSITIVE LIPASE TO α2-ADRENOCEPTOR ACTIVATION BY UK 14304 Alcohol Alcohol. 2001;36(5):381-387. doi:10.1093/alcalc/36.5.381 Alcohol Alcohol | © 2001 Medical Council on Alcohol

Hormone-sensitive lipase activity (a) is expressed as nmol of free fatty acids released per min per mg of tissue protein. cAMP accumulation (b) is expressed as nmol/mg of tissue protein. Acute ethanol treatment was a single dose of 2.5 g/kg i.p. 60 min prior to the assays. Chronic ethanol treatment consisted of 20% ethanol as sole drinking fluid for 4 weeks. The results are shown as means ± SEM from 20–24 mice for lean groups and 8–10 mice for obese groups. ¶P < 0.05, ¶¶P < 0.01 ethanol > control. EFFECTS OF ACUTE AND CHRONIC ETHANOL ADMINISTRATION ON THE RESPONSE OF MOUSE ADIPOSE TISSUE HORMONE-SENSITIVE LIPASE TO α2-ADRENOCEPTOR ACTIVATION BY UK 14304 Alcohol Alcohol. 2001;36(5):381-387. doi:10.1093/alcalc/36.5.381 Alcohol Alcohol | © 2001 Medical Council on Alcohol

The results are shown as means ± SEM from 20–24 mice per group The results are shown as means ± SEM from 20–24 mice per group. ¶P < 0.05 obese > lean mice; **P < 0.01 obese < lean mice. EFFECTS OF ACUTE AND CHRONIC ETHANOL ADMINISTRATION ON THE RESPONSE OF MOUSE ADIPOSE TISSUE HORMONE-SENSITIVE LIPASE TO α2-ADRENOCEPTOR ACTIVATION BY UK 14304 Alcohol Alcohol. 2001;36(5):381-387. doi:10.1093/alcalc/36.5.381 Alcohol Alcohol | © 2001 Medical Council on Alcohol

The results are shown as means ± SEM from 20–24 mice per group The results are shown as means ± SEM from 20–24 mice per group. ¶P < 0.05 experimental group > control lean. EFFECTS OF ACUTE AND CHRONIC ETHANOL ADMINISTRATION ON THE RESPONSE OF MOUSE ADIPOSE TISSUE HORMONE-SENSITIVE LIPASE TO α2-ADRENOCEPTOR ACTIVATION BY UK 14304 Alcohol Alcohol. 2001;36(5):381-387. doi:10.1093/alcalc/36.5.381 Alcohol Alcohol | © 2001 Medical Council on Alcohol

Hormone-sensitive lipase activity in brown (a) or white (b) adipose tissue is expressed as nmol of free fatty acids released per min per mg tissue protein. The results are shown as means ± SEM from groups of six mice each and were combined from different experimental days. Mice received saline or UK 14304 60 min prior to the assay. **P < 0.01 versus saline control; ¶P < 0.05, ¶¶P < 0.01 obese saline versus lean saline. EFFECTS OF ACUTE AND CHRONIC ETHANOL ADMINISTRATION ON THE RESPONSE OF MOUSE ADIPOSE TISSUE HORMONE-SENSITIVE LIPASE TO α2-ADRENOCEPTOR ACTIVATION BY UK 14304 Alcohol Alcohol. 2001;36(5):381-387. doi:10.1093/alcalc/36.5.381 Alcohol Alcohol | © 2001 Medical Council on Alcohol

Hormone-sensitive lipase activity in brown (a) or white (b) adipose tissue is expressed as nmol of free fatty acids released per min per mg tissue protein. The results are shown as means ± SEM from groups of six mice each and were combined from different experimental days. Mice received saline or UK 14304 60 min prior to the assay. **P < 0.01 versus saline control; ¶P < 0.05, ¶¶P < 0.01 obese saline versus lean saline. EFFECTS OF ACUTE AND CHRONIC ETHANOL ADMINISTRATION ON THE RESPONSE OF MOUSE ADIPOSE TISSUE HORMONE-SENSITIVE LIPASE TO α2-ADRENOCEPTOR ACTIVATION BY UK 14304 Alcohol Alcohol. 2001;36(5):381-387. doi:10.1093/alcalc/36.5.381 Alcohol Alcohol | © 2001 Medical Council on Alcohol

Hormone-sensitive lipase activity (a) is expressed as nmol of free fatty acids released per min per mg of tissue protein. cAMP accumulation (b) is expressed as nmol/mg of tissue protein. Control (untreated) and chronic ethanol drinking (CED) groups received saline or UK 14304 (1 mg/kg) 60 min prior to the assay. The results are shown as means ± SEM from 20–24 mice for lean groups, 16–20 mice for obese groups, and 8–10 mice for UK 14304-treated groups. †P < 0.05 obese versus lean; *P < 0.05 chronic ethanol < control; ¶P < 0.05 chronic ethanol > control. EFFECTS OF ACUTE AND CHRONIC ETHANOL ADMINISTRATION ON THE RESPONSE OF MOUSE ADIPOSE TISSUE HORMONE-SENSITIVE LIPASE TO α2-ADRENOCEPTOR ACTIVATION BY UK 14304 Alcohol Alcohol. 2001;36(5):381-387. doi:10.1093/alcalc/36.5.381 Alcohol Alcohol | © 2001 Medical Council on Alcohol