Evaluation of the Test-mate ChE (Cholinesterase) Field Kit in Acute Organophosphorus Poisoning Bishan N. Rajapakse, MBChB, Horst Thiermann, MD, Peter.

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Presentation transcript:

Evaluation of the Test-mate ChE (Cholinesterase) Field Kit in Acute Organophosphorus Poisoning Bishan N. Rajapakse, MBChB, Horst Thiermann, MD, Peter Eyer, MD, Franz Worek, MD, PhD, Steven J. Bowe, M Med Stat, PhD, Andrew H. Dawson, MBBS, FRACP, Nicholas A. Buckley, MD, FRACP Annals of Emergency Medicine Volume 58, Issue 6, Pages 559-564.e6 (December 2011) DOI: 10.1016/j.annemergmed.2011.07.014 Copyright © 2011 American College of Emergency Physicians Terms and Conditions

Figure 1 A, Scatter diagram showing RBC AChE activity determined by the Test-mate ChE field kit plotted against activity determined by the reference test. The different clinical categories for levels of RBC AChE inhibition (normal, mild, moderate, and severe) are indicated by dotted lines. B, Scatter diagram showing the Test-mate PChE activity plotted against the reference test PChE activity (*after adjustment to units per milliliter of whole blood). The line of equality is represented by a dotted line. The limit of quantification for the Test-mate ChE (0.26 U/mL) is marked on the y axis. LOQ, Limit of quantification. Annals of Emergency Medicine 2011 58, 559-564.e6DOI: (10.1016/j.annemergmed.2011.07.014) Copyright © 2011 American College of Emergency Physicians Terms and Conditions

Figure 2 Bland-Altman plots showing the difference measurement between the Test-mate ChE and reference test results plotted against the mean of both methods for (a) RBC AChE and (b) PChE (*after adjustment to units per milliliter of whole blood). Horizontal lines represent the mean bias and 95% limits of agreement. The limit of quantification for PChE measurement by Test-mate ChE (0.26 U/mL) is marked by a vertical dotted line. Annals of Emergency Medicine 2011 58, 559-564.e6DOI: (10.1016/j.annemergmed.2011.07.014) Copyright © 2011 American College of Emergency Physicians Terms and Conditions

Figure E1 Flowchart showing criteria used for patient selection. Annals of Emergency Medicine 2011 58, 559-564.e6DOI: (10.1016/j.annemergmed.2011.07.014) Copyright © 2011 American College of Emergency Physicians Terms and Conditions

Figure E2 Protocol for frequency of AChE blood testing. Symptomatic patients were tested more frequently than asymptomatic patients, and those receiving oxime therapy were tested pre- and postpralidoxime dose. Annals of Emergency Medicine 2011 58, 559-564.e6DOI: (10.1016/j.annemergmed.2011.07.014) Copyright © 2011 American College of Emergency Physicians Terms and Conditions

Figure E3 Bland-Altman plot showing the difference between methods against the average of the 2 (by the subject number). Annals of Emergency Medicine 2011 58, 559-564.e6DOI: (10.1016/j.annemergmed.2011.07.014) Copyright © 2011 American College of Emergency Physicians Terms and Conditions

Figure E4 A, Scatter diagram showing the Test-mate PChE activity limited to results above the limits of quantification (0.26 U/mL), plotted against the reference test PChE activity (*after adjustment to units/milliliter of whole blood). The line of equality is represented by a dotted line. B, Bland-Altman plots showing the difference measurement between the Test-mate ChE and reference test results plotted against the mean of both methods for PChE (*after adjustment to units/milliliter of whole blood). Horizontal lines represent the mean bias and 95% limits of agreement, and vertical dotted line represents the limits of quantification (0.26 U/mL). Results have been restricted to values above the limits of quantification for the Test-mate ChE. Annals of Emergency Medicine 2011 58, 559-564.e6DOI: (10.1016/j.annemergmed.2011.07.014) Copyright © 2011 American College of Emergency Physicians Terms and Conditions