An Introduction to Derwent World Drug Index Richard Lambert Pharmaceutical Product Manager

World Drug Index - Background World Drug Index launched in 1994 Originated from Standard Drug File (SDF) Coverage back to 1964 Contains only named compounds, including Trial Preparation Codes Released on a quarterly cumulative basis

World Drug Index - What is it? Integrated drug database containing marketed drugs drugs in development new chemical entities (NCE’s) from scientific literature or reported at conferences Text and structure searchable 20 searchable fields with controlled keywords Standard conventions for selection and structure input

World Drug Index - Coverage/Selection Guidelines Source Materials Literature articles from over 1,200 journals Conference proceedings (approx. 20 per year) Pharmacopoeias and Approved Name Lists Selection Criteria All named compounds from the Derwent Drug File All named compounds from Conference Fast-Track Named compounds from pharmacopoeias and approved name lists (e.g. USAN and INN)

World Drug Index - Statistics Over 64,000 drug records 4000 new records per annum 16,000 updates to existing records per annum Over 203,000 synonyms 12,000 Approved Names 34,000 Trial Preparation Codes 144,000 Trade Names/Trivial Names 13,000 Combination Names Over 20,000 source references (added since 1994)

World Drug Index - Data fields Derwent Drug Name Structure Derwent Registry Name Pharmacological Activity / Mechanism of Action Reference Chemical Substructure keywords Synonyms Biomedical Data

World Drug Index - Features/Uses Structure/sub-structure activity relationships Archive reference file for marketed and development drugs Information on drug manufacturers and countries of origin/sale Trade name and synonym searching

World Drug Index - Daylight’s Implementation Full Version Lite Version Includes: Structural data Synonyms Activity Excludes: Mechanism of Action Biomedical Information

World Drug Index - HTML Version Simple intuitive interface Text fields Names CAS numbers Smiles Structure searchable using GRINS Exact Substructure Superstructure