Monitoring compliance to therapy during addiction treatments by means of hair analysis for drugs and drug metabolites using capillary zone electrophoresis.

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Monitoring compliance to therapy during addiction treatments by means of hair analysis for drugs and drug metabolites using capillary zone electrophoresis coupled to time-of- flight mass spectrometry Rossella Gottardo, Ameriga Fanigliulo, Daniela Sorio, Eloisa Liotta, Federica Bortolotti, Franco Tagliaro Forensic Science International Volume 216, Issue 1, Pages 101-107 (March 2012) DOI: 10.1016/j.forsciint.2011.09.004 Copyright © 2011 Elsevier Ireland Ltd Terms and Conditions

Fig. 1 Fig. 1 Total ion electropherogram (top) and overlapped (reconstructed) electropherogram (bottom) from hair extract of CASE 1. Identified peaks: MT 11.2min, m/z 278.1907, EDDP; MT 11.3 and 11.5min, m/z 230.2485 and 230.1768 respectively, peaks from matrix; MT 11.6min, m/z 310.2149, methadone; MT 11.9min, m/z 331.1458, des-methyl-levomepromazine-sulfoxide; MT 12.7min, m/z 345.1615, levomepromazine-sulfoxide; MT 13.0min, m/z 197.0849, m-chlorophenylpiperazine; MT 13.8min, m/z 163.1260, nicotine. For analytical conditions, see text. Forensic Science International 2012 216, 101-107DOI: (10.1016/j.forsciint.2011.09.004) Copyright © 2011 Elsevier Ireland Ltd Terms and Conditions

Fig. 2 Total ion electropherogram (top) and overlapped (reconstructed) electropherogram (bottom) from hair extract of CASE 2. Identified peaks: MT 10.1min, m/z 230.2485, peak from matrix; MT 10.4min, m/z 311.1569, des-methyl-citalopram; MT 10.8min, m/z 325.1710, escitalopram; MT 11.3min, m/z 318.1702, cocaethylene; MT 11.5min, m/z 304.1546, cocaine; MT 11.6min, m/z 197.0849, m-chlorophenylpiperazine. For analytical conditions, see text. Forensic Science International 2012 216, 101-107DOI: (10.1016/j.forsciint.2011.09.004) Copyright © 2011 Elsevier Ireland Ltd Terms and Conditions

Fig. 3 Total ion electropherogram (top) and overlapped (reconstructed) electropherogram (bottom) from hair extract of CASE 3. Identified peaks: MT 12.4 and 12.6min, m/z 230.2477 and 230.1748 respectively, peaks from matrix; MT 13.5min, m/z 325.1699, escitalopram; MT 14.1min, m/z 318.1683, cocaethylene; MT 14.4min, m/z 304.1527, cocaine; MT 15.1min, m/z 290.1388, benzoylecgonine; MT 15.3min, m/z 163.1249, nicotine. For analytical conditions, see text. Forensic Science International 2012 216, 101-107DOI: (10.1016/j.forsciint.2011.09.004) Copyright © 2011 Elsevier Ireland Ltd Terms and Conditions

Fig. 4 Total ion electropherogram (top) and overlapped (reconstructed) electropherogram (bottom) from hair extract of CASE 4. Identified peaks: MT 11.7min, m/z 278.1894, EDDP; MT 12.1min, m/z 310.2163, methadone; MT 14.4min, m/z 300.1600, codeine; MT 14.9, m/z 328.1536, 6-MAM; MT 15.0min, m/z 286.1438, morphine. For analytical conditions, see text. Forensic Science International 2012 216, 101-107DOI: (10.1016/j.forsciint.2011.09.004) Copyright © 2011 Elsevier Ireland Ltd Terms and Conditions

Fig. 5 Total ion electropherogram (top) and overlapped (reconstructed) electropherogram (bottom) from hair extract of CASE 5. Identified peaks: MT 11.5min, m/z 311.1546, des-methyl-citalopram; MT 12.0min, m/z 325.1689, citalopram; MT 12.9min, m/z 251.1754, rivastigmine; MT 13.0min, m/z 166.1248, rivastigmine metabolite. For analytical conditions, see text. Forensic Science International 2012 216, 101-107DOI: (10.1016/j.forsciint.2011.09.004) Copyright © 2011 Elsevier Ireland Ltd Terms and Conditions