Development and validation of a liquid chromatography–tandem mass spectrometry assay for hair analysis of atomoxetine and its metabolites: Application.

Slides:

Advertisements

Similar presentations

The most efficient STR loci in forensic genetics in population of central Poland R. Jacewicz, M. Jedrzejczyk, J. Berent Forensic Science International:

Advertisements

Quality analysis of Polygala tenuifolia root by ultrahigh performance liquid chromatography–tandem mass spectrometry and gas chromatography–mass spectrometry

Illa Tea, Ingrid Antheaume, Ben-Li Zhang

The importance of Guthrie cards and other medical samples for the direct matching of disaster victims using DNA profiling D. Hartman, L. Benton, L. Morenos,

DNA profiling of trace DNA recovered from bedding

Right heart ischemia in cases of sepsis

Cyanide quantification in post-mortem biological matrices by headspace GC–MS Brigitte Desharnais, Geneviève Huppé, Martine Lamarche, Pascal Mireault,

Buprenorphine and major metabolites in blood specimens collected for drug analysis in law enforcement purposes Stephanie Oechsler, Gisela Skopp Forensic.

Analysis of Indian blue ballpoint pen inks tagged with rare-earth thenoyltrifluoroacetonates by inductively coupled plasma–mass spectrometry and instrumental.

The ideal subject distance for passport pictures

Volatile organic compounds in polyethylene bags⿿A forensic perspective

Real time quantitative colourimetric test for methamphetamine detection using digital and mobile phone technology Aree Choodum, Kaewalee Parabun, Nantikan.

Fast LC–MS/MS method for the determination of amphetamine, methamphetamine, MDA, MDMA, MDEA, MBDB and PMA in urine Marta Concheiro, Susana Maria dos.

Two fatal intoxication cases with imidacloprid: LC/MS analysis

The effect of sodium fluoride on the stability of cyanide in postmortem blood samples from fire victims J.L. McAllister, R.J. Roby, Barry Levine, David.

Ethanol production by Candida albicans in postmortem human blood samples: Effects of blood glucose level and dilution Daisuke Yajima, Hisako Motani,

Piotr Adamowicz, Dariusz Zuba, Karolina Sekuła

Előd Hidvégi, Péter Fábián, Zsuzsa Hideg, Gábor Somogyi

A snapshot on NPS in Italy: Distribution of drugs in seized materials analysed in an Italian forensic laboratory in the period 2013–2015 Sara Odoardi,

A snapshot on NPS in Italy: Distribution of drugs in seized materials analysed in an Italian forensic laboratory in the period 2013–2015 Sara Odoardi,

Determination of ketamine and norketamine in hair by micropulverized extraction and liquid chromatography–high resolution mass spectrometry Donata Favretto,

Simultaneous determination of mushroom toxins α-amanitin, β-amanitin and muscarine in human urine by solid-phase extraction and ultra-high-performance.

Detection of 3-methylmethcathinone and its metabolites 3-methylephedrine and 3- methylnorephedrine in pubic hair samples by liquid chromatography–high.

Purple discoloration of the colon found during autopsy: Identification of betanin, its aglycone and metabolites by liquid chromatography–high-resolution.

Simultaneous analysis of six amphetamines and analogues in hair, blood and urine by LC-ESI-MS/MS Marjorie Chèze, Marc Deveaux, Claire Martin, Michel.

Optimization of an analytical method for detecting paraphenylenediamine (PPD) by GC/MS-iontrap in biological liquids A. Stambouli, M.A. Bellimam, N.

The homogeneity testing of EtG in hair reference materials: A high-throughput procedure using GC–NCI–MS Bettina Mönch, Roland Becker, Christian Jung,

A high-throughput urinalysis of abused drugs based on a SPE-LC–MS/MS method coupled with an in-house developed post-analysis data treatment system Wing-Chi.

Yun Sik Nam, Il Keun Kwon, Yeonhee Lee, Kang-Bong Lee

UPLC-MS/MS determination in blood of a mixed-drug fatal intoxication: A case report Paula Proença, João Miguel Franco, Carla Mustra, Carla Monteiro, Joana.

Gowri Vijay Reesu, Nathan Lee Brown Forensic Science International

Inhwan Han Forensic Science International

Comparing ballistic wounds with experiments on body simulator

An investigation into the behaviour of air rifle pellets in ballistic gel and their interaction with bone G. Wightman, J. Beard, R. Allison Forensic.

Identification, extraction and quantification of the synthetic cannabinoid JWH-018 from commercially available herbal marijuana alternatives Sage J.B.

Cuiling Zhang, Joost van de Weijer, Jingxu Cui

Suspected clozapine poisoning in the UK/Eire, 1992–2003

Suspected clozapine poisoning in the UK/Eire, 1992–2003

Elemental analysis of glass by laser ablation inductively coupled plasma optical emission spectrometry (LA-ICP-OES) Emily R. Schenk, José R. Almirall

Előd Hidvégi, Péter Fábián, Zsuzsa Hideg, Gábor Somogyi

Instability of calcium channel antagonists during sample preparation for LC–MS–MS analysis of serum samples Ana B. Baranda, Rosa M. Alonso, Rosa M. Jiménez,

The discrimination of automotive clear coats by pyrolysis-gas chromatography/mass spectrometry and comparison of samples by a chromatogram library software

Forensic Science International

Comparison of latex body paint with wetted gauze wipes for sampling the chemical warfare agents VX and sulfur mustard from common indoor surfaces Laura.

Monitoring compliance to therapy during addiction treatments by means of hair analysis for drugs and drug metabolites using capillary zone electrophoresis.

Relationship between methamphetamine use history and segmental hair analysis findings of MA users Eunyoung Han, Sangeun Lee, Sanghwan In, Meejung Park,

Evidence of mephedrone chronic abuse through hair analysis using GC/MS

Evidence of mephedrone chronic abuse through hair analysis using GC/MS

Development and validation of a liquid chromatography–tandem mass spectrometry assay for hair analysis of atomoxetine and its metabolites: Application.

Forensic classification of counterfeit banknote paper by X-ray fluorescence and multivariate statistical methods Hongling Guo, Baohua Yin, Jie Zhang,

Simultaneous determination of creatinine and uric acid in urine by liquid chromatography–tandem mass spectrometry with polarity switching electrospray.

Simultaneous determination of creatinine and uric acid in urine by liquid chromatography–tandem mass spectrometry with polarity switching electrospray.

Natalija Novokmet, Zlatko Pavčec Forensic Science International

An evaluation of miniSTR markers for casework applications

A. Barbaro, P. Cormaci, G. Falcone

Establishment of Italian national DNA database and the central laboratory: Some aspects R. Biondo, F. De Stefano Forensic Science International: Genetics.

Population data for SE33 locus in United Arab Emirates Arab population

Development of a SNP-STRs multiplex for forensic identification

Christina Valgren, Sara Wester, Oskar Hansson

Efficient DNA extraction from hair shafts

A 50 SNP-multiplex mass spectrometry assay for human identification

Ronny Decorte, Chi Fung Liu, Nancy Vanderheyden, Jean-Jacques Cassiman

Analysis of forensic samples in Banco Nacional de Datos Genéticos

Developmental validation of a fully automated genotyping assay capable of detecting length and sequence variation in the CODIS STR loci David D. Duncan,

M. Hara, T. Masuda, A. Takada, T. Miyazaki, H. Suzuki, A. Kido, K

Application of less primer method to commercial kits

Effects of the most common methods for the enhancement of latent fingerprints on DNA extraction from forensic samples S. Gino, M. Omedei Forensic Science.

M. Lurdes Pontes, M. Fátima Pinheiro

Improved performance for forensic casework: Extraction and isolation updates for the Maxwell® 16 instrument M. Lindner, P.V. Mandrekar, J. Bessetti,

S. Cardoso, M. C. González-Fernández, A. Odriozola, L. Valverde, M. M

Presentation transcript:

Development and validation of a liquid chromatography–tandem mass spectrometry assay for hair analysis of atomoxetine and its metabolites: Application in clinical practice Esther Papaseit, Emilia Marchei, Claudia Mortali, Gemma Aznar, Oscar Garcia-Algar, Magi Farrè, Roberta Pacifici, Simona Pichini Forensic Science International Volume 218, Issue 1, Pages 62-67 (May 2012) DOI: 10.1016/j.forsciint.2011.10.012 Copyright © 2011 Elsevier Ireland Ltd Terms and Conditions

Fig. 1 LC–MS/MS chromatogram of drug-free hair sample spiked at the low quality control concentration (0.3ng/mg) for 4-hydroxyatomoxetine, N-desmethylatomoxetine and atomoxetine and spiked with 50ng/mg for risperidone, sertraline and carbamazepine. Duloxetine (IS) is 5ng/mg. Forensic Science International 2012 218, 62-67DOI: (10.1016/j.forsciint.2011.10.012) Copyright © 2011 Elsevier Ireland Ltd Terms and Conditions

Fig. 2 LC–MS/MS chromatogram of a hair sample extract containing: 0.49ng/mg 4-hydroxyatomoxetine, 0.64ng/mg risperidone, 0.90ng/mg atomoxetine, 29.81ng/mg sertraline, and 5ng/mg duloxetine (IS). Forensic Science International 2012 218, 62-67DOI: (10.1016/j.forsciint.2011.10.012) Copyright © 2011 Elsevier Ireland Ltd Terms and Conditions