From: Ketamine Inhibits Glutamate-, N-Methyl-D-Aspartate-, and Quisqualate-stimulated cGMP Production in Cultured Cerebral Neurons Anesthes. 1995;82(1):205-213.

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From: Ketamine Inhibits Glutamate-, N-Methyl-D-Aspartate-, and Quisqualate-stimulated cGMP Production in Cultured Cerebral Neurons Anesthes. 1995;82(1):205-213. Figure Legend: Figure 5. Effect of ketamine on GLU-, NMDA-, and QUIS-stimulated cGMP production in cultured neurons. The effect of various concentrations of ketamine on cGMP production was determined in neuronal cultures stimulated by GLU and the GLU analogs NMDA and QUIS. Data represent the mean plus/minus SEM for n = 5–27 experiments, each performed in triplicate. The results from individual experiments were normalized and the data expressed as the percent of the agonist-stimulated value in the absence of ketamine (100%)(control basal - 18 plus/minus 2 pmol *symbol* mg protein sup -1, GLU-stimulated control value = 96 plus/minus 15 pmol *symbol* mg protein sup -1, NMDA-stimulated control value = 127 plus/minus 26. pmol *symbol* mg protein sup -1, QUIS-stimulated control value = 90 plus/minus 16 pmol *symbol* mg protein sup -1). *P < 0.05 versus control without ketamine for that agonist, by ANOVA and Bonferroni post boc correction. (dagger)P < 0.05 versus NMDA-stimulated value in presence of 10 micro Meter ketamine. Date of download: 11/7/2017 Copyright © 2017 American Society of Anesthesiologists. All rights reserved.