From: Changes in the Photoreceptor Mosaic of P23H-1 Rats During Retinal Degeneration: Implications for Rod-Cone Dependent Survival Invest. Ophthalmol.

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From: Changes in the Photoreceptor Mosaic of P23H-1 Rats During Retinal Degeneration: Implications for Rod-Cone Dependent Survival Invest. Ophthalmol. Vis. Sci.. 2013;54(8):5888-5900. doi:10.1167/iovs.13-12643 Figure Legend: Rod and cone degeneration in the P23H-1 rat: analysis in flat-mounted retinas. (A) Photomontage of a whole-mounted retina from a P23H-1 animal processed at P180 showing rods (rhodopsin signal in red) and all cones (S- and L/M- opsins detected with the same fluorophore, green). At this postnatal time, most rods have disappeared from the retina, except at the extreme retinal periphery. Throughout the retina, degeneration rings delineated by rods and cones are observed. (B–J) Magnifications from whole-mounted P23H-1 retinas immunodetected as retina in (A) and analyzed at P90 (B–F) or 180 (G–J). (B, C, G, H) Images were acquired from the ventral retina and (E, F, I, J) from the dorsal retina. At both postnatal times, rhodopsin was more abundant in the ventral (B, C, G, H) than in the dorsal (E, F, I, J) retina. Rings delineated by rods and cones are already observed at P90, but at P180 in the ventral retina they have rhodopsin in their border (G, H) while in the dorsal retina (I, J) rhodopsin expression is lost. Scale bars: 1 mm in (A) and 100 μm in (B–J). Date of download: 11/7/2017 The Association for Research in Vision and Ophthalmology Copyright © 2017. All rights reserved.