Figure 1. (A) Mean MPPF BPND concentration at basal state in ASD patients group (N = 18), color bar = MPPF BP<sub>ND</sub> value. The color bar represents.

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Figure 1. (A) Mean MPPF BPND concentration at basal state in ASD patients group (N = 18), color bar = MPPF BP<sub>ND</sub> value. The color bar represents MPPF BP<sub>ND</sub>. (B) Bar plot showing between group comparison (HC and patients (ASD)) for BP values at basal state in each region of interest. No statistical differences were found between patients and controls. Error bars indicate SEM. From: Oxytocin Fails to Recruit Serotonergic Neurotransmission in the Autistic Brain Cereb Cortex. Published online October 17, 2017.1-10 doi:10.1093/cercor/bhx272 Cereb Cortex | © The Author 2017. Published by Oxford University Press. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com

Figure 2. T-map SPM within subject analysis (baseline vs Figure 2. T-map SPM within subject analysis (baseline vs. spray, P < 0.01, T > 2.41) showing for ROI (comprised in the mask) the effect of OT administration on MPPF BP<sub>ND</sub> compared to basal state in HC (left) and in ASD patients (middle, no effects), (A) dorsal raphe nuclei, (B) amygdala, (C) insula, and (D) OFC. (right). Binding potential values for each group (light gray = controls, 12 per treatment group; dark gray = patients, 9 per treatment group) for each condition and each ROI; *indicates a significant difference induced by OT on MPPF BP<sub>ND</sub> variation (1-sample t-test P < 0.05). T-maps are projected on the anatomical mean image of each group. Note that in the patients group, while some isolated voxels showed significant differences, there were no significant clusters. From: Oxytocin Fails to Recruit Serotonergic Neurotransmission in the Autistic Brain Cereb Cortex. Published online October 17, 2017.1-10 doi:10.1093/cercor/bhx272 Cereb Cortex | © The Author 2017. Published by Oxford University Press. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com

Figure 3. Serum free serotonin concentration before and after spray for each spray treatment (OT vs. placebo) and group (HC vs. ASD), black dotted lines represent individuals. From: Oxytocin Fails to Recruit Serotonergic Neurotransmission in the Autistic Brain Cereb Cortex. Published online October 17, 2017.1-10 doi:10.1093/cercor/bhx272 Cereb Cortex | © The Author 2017. Published by Oxford University Press. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com

Figure 4. Correlation between serum free serotonin concentration and DRN MPPF BP<sub>ND</sub> in HCs (N = 22, rho = 0.44, P < 0.05) and patients group (N = 16, rho = 0.61, P < 0.05) from the baseline scan. From: Oxytocin Fails to Recruit Serotonergic Neurotransmission in the Autistic Brain Cereb Cortex. Published online October 17, 2017.1-10 doi:10.1093/cercor/bhx272 Cereb Cortex | © The Author 2017. Published by Oxford University Press. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com