SQUAMOUS PAPILLOMA

a benign proliferation of stratified squamous epithelium. a papillary or verruciform mass

a soft, painless, usually pedunculated, exophytic nodule with numerous fingerlike surface projections ("cauliflower" or wartlike appearance )

human papillomavirus (HPV) at least 24 types are associated with lesions of the head and neck totally integration with the DNA of the host cell Viral subtypes 6 and 11 have been identified in up to 50% of oral papillomas less than 5% in normal mucosal cells.

the most common of the soft tissue masses arising from the soft palate

Pointed projections blunted projections

A firm, white, rough, exophytic, pedunculated, nontender soft tissue enlargement on the right ventral tongue.

Histopathologic Features a proliferation of keratinized stratified squamous epithelium arrayed in fingerlike projections

fibrovascular connective tissue cores may show inflammatory changes

hyperkeratosis . acanthosis loose connective tissue

Keratin layer Granular layer

Occasional ………basilar hyperplasia and mitotic activity a normal maturation pattern

Koilocytes virus-altered epithelial clear cells with small dark (pyknotic) nuclei in the prickle cell layer keratohyaline granules cleared cytoplasm, shrunken, irregular nuclei