Lecture 23 Quiz 6 Average = 72% (36 out of 50) Mass Spectrometry

Slides:

Advertisements

Similar presentations

Organic Spectroscopy Mass Spectrometry.

Advertisements

Advanced Higher Unit 3 Mass Spectrometry. Mass spectrometry can be used to determine the accurate molecular mass and structural features of an organic.

Mass Spectrometry Courtesy Purpose of Mass Spectrometry  Produces spectra of masses from the molecules in a sample of material, and.

Chapter 14 Mass Spectroscopy.

Mass Spectrometry The substance being analyzed (solid or liquid) is injected into the mass spectrometer and vaporized at elevated temperature and reduced.

MiniQuiz 6 Answers: Which of the compounds below do you expect to absorb light in the UV-region? (circle) Hexane Ethanol Benzene Naphthalene Explain your.

Today: Brief Review of Mass Spectroscopy Discussion/Review of H-NMR, CMR Next time (our last lab lecture): Your questions Final Exam at 2:10 pm in your.

Mechanism of Phenylurethane

Molecular weight: Molecular ion peak M + ? odd-numbered (N...) ? isotope peaks (Cl, Br)? Alcohols … Recognize typical fragments: H 2 O, alkyl, acyl, tropylium.

Check your Unknown #3 mass spectrum

Complete this reaction equation:

Introduction to Mass Spectrometry (MS)

William H. Brown & Christopher S. Foote

13.22 Mass Spectrometry. Atom or molecule is hit by high-energy electron Principles of Electron-Impact Mass Spectrometry e–e–e–e–

13.21 Mass Spectrometry. Atom or molecule is hit by high-energy electron Principles of Electron-Impact Mass Spectrometry e–e–e–e–

Mass Spectrometry. Atom or molecule is hit by high-energy electron Principles of Electron-Impact Mass Spectrometry e–e–e–e–

CH 908: Mass Spectrometry Lecture 4 Interpreting Electron Impact Mass Spectra – Continued… Recommended: Read chapters 8-9 of McLafferty Prof. Peter B.

Organic Mass Spectrometry

Intro to Spectroscopy Ch 12: Spectral Unknown HDI (Hydrogen Deficiency Index) Lecture Problem 1 Due This week in lab: Ch 4: Recrystallization & Melting.

CHEM 344 Organic Chemistry Lab January 20 th & 21 st 2009 Structural Determination of Organic Compounds Lecture 1 – Mass Spectrometry.

Unit 3: Stoichiometry Part 1. Atomic Masses Atomic mass – (atomic weight) – The atomic mass of an element indicates how heavy, on average, an atom of.

AS 2.12 Mass spectra a. interpret fragment ion peaks in the mass spectra of simple organic compounds, eg the difference between propanal and propanone.

Mass spectrometry L.O.: Understand how fragmentation can be useful to find the molecular structure.

Menu We will look at some of the major peaks in the mass spectrum of butane.

11 CHEM 344 Organic Chemistry Lab September 9 th and 10 th 2008 Spectroscopy of Organic Compounds Lecture 3 –Infrared and Mass Spec.

In MS a molecule is vaporized and ionized by bombardment with a beam of high-energy electrons. E = 1600 kcal (or 70 eV). C-C BDE = 100 kcal Mass Spectrometry.

Created with MindGenius Business 2005® Isotopes (1) Isotopes (1) It is important to use the correct method to calculate molecular weight for MS. Average.

MC 13.3 Spectroscopy, Pt III 1 Introduction to Mass Spectrometry (cont) Principles of Electron-Impact Mass Spectrometry:  A mass spectrometer produces.

111 CHEM 344 Organic Chemistry Lab June 18 th 2008 Spectroscopy of Organic Compounds Lecture 3 –Infrared and Mass Spec Nick Hill.

CONTENTS Fragmentation of molecular ions - theory What a mass spectrum tells you Molecular ions Fragmentation Mass spectra of alkanes Mass spectra of halogenoalkanes.

IR and Mass Spec Webquest Suzanna Newton 12 Fisher.

STRUCTURAL DETERMINATION MASS SPECTRUM (MS) LAB 12.

In carbon-13 NMR, what do the number of peaks represent? The number of chemically different carbon atoms present.

Prepared by Lawrence Kok Tutorial on Mass Spectrometer and Isotopes.

12. Structure Determination: Mass Spectrometry

Mass Spectrometry u Chapter 12 Chapter 12.

MASS SPECTROSCOPY (with Gas Chromatography). 5 Stages of the process – where do they happen? 1.Sample vaporised 2.Sample ionised 3.Ions accelerated 4.Ions.

Chemical Measurements

Chemical Ideas 6.5 Mass spectrometry.

Atomic structure L.O. To be able to recall definitions of relative atomic, isotopic and molecular mass. To demonstrate an understanding of the basic.

FURTHER MASS SPECTROMETRY KNOCKHARDY PUBLISHING

Ionization techniques, Mass spectra and MS-Instrumentation

Atomic structure L.O. 1. To be able to recall definitions of relative atomic, isotopic and molecular mass. 2. To learn about the key principles of mass.

R W Grime Ripon Grammar School

Organic Chemistry Lesson 18 Mass spectrometry.

Mass Spectrometry Courtesy

FH2O2Resonance [α]λ SN1E1 ME2SOCl2 TS Enan R. Chem Fall, 2014

Introduction to Mass Spectrometry (MS)

C2.8 Instrumental Analysis

Mass Spectrometry Courtesy

Chemsheets AS007 (Mass spectroscopy)

Balancing Equations.

Lecture 22 Introduction to Mass Spectrometry Lecture Problem 7 Due

General Overview of the module and the methods

Determination of Structure

Mass Spectrometry Courtesy

Mass spectrometry Detection of ionic species to determine the molecular weight of and obtain structural information on a molecule.

Mass Spectrometry (MS)

Unit Objectives 1)understand the evolution of models of the atom: Dalton, Thomson, Rutherford, Bohr, the ‘quantum model 2) understand the meaning of mass.

Chemistry - Option A : Modern Analytical Chemistry

MASS SPECTRA measure a compound’s Mol. Wt.

FURTHER MASS SPECTROMETRY KNOCKHARDY PUBLISHING

In this lesson you will learn:

FURTHER MASS SPECTROMETRY KNOCKHARDY PUBLISHING

TOPIC 9. STRUCTURE DETERMINATION (chapter 9 and part of chapter 2)

9. STRUCTURE DETERMINATION

Presentation transcript:

Lecture 23 Quiz 6 Average = 72% (36 out of 50) Mass Spectrometry This week in lab: Ch 9 Final Report Due Synthetic #2 PreLab Due Next week in lab: Synthetic #1 Final Report Due

Molecular Ions Molecular Ions = sum of atomic weight(s) of all isotopes of all elements in a molecule. If you had 10,000 atoms of each type: C: 9890 12C atoms 110 13C atoms H: 9999 1H atoms 1 2H atoms O: 9985 16O atoms, 4 17O atoms, 20 18O atoms N: 9963 14N atoms 37 15N atoms Cl: 7577 35Cl atoms 2423 37Cl atoms (3:1 35Cl:37Cl) Br: 5069 79Br atoms 4931 81Br atoms (1:1 79Br:81Br)

Molecular Ions: Cl & Br Compounds - Isotopes Significant M+2 peak => Cl or Br Cl is 3 parts 35Cl and 1 part 37Cl Br is 1:1 79Br and 81Br

MS of Chlorobenzene M+ C6H535Cl = m/z 112 C6H537Cl = m/z 114 Note ratio: m/z 112:114 is 3:1 M + 2

MS of Bromobenzene C6H579Br = m/z 156 C6H581Br = m/z 158 M+ = 156 Note ratio: 156:158 1:1

Mass Spec Correlation Chart #1 Common fragments ions and/or neutral losses: 15 can only be methyl 17 usually OH 18 always H2O 28 CO or CH2=CH2 29 CH3CH2 or CHO 31 CH3O 35/37 Cl (special isotope pattern too!) 42 CH2=C=O 43 CH3CO or C3H7 45 CH3CH2O or COOH 79/81 Br (special isotope pattern too!)

Mass Spec Correlation Chart #2 Weights of common fragments or neutral losses:

Lab Guide Problems Problem 15.3 Mass spec shown in class (Figure 15.11) Account for the peaks at m/z values of 88 (M+) , 73, 70, 59, and 55.

Lab Guide Problems Problem 15.5 Account for the peaks in the mass spectrum of 2-octanone at m/z values of 129 (M+1), 128 (M+), 113, 85, and 43.

Lab Guide Problems Problem 19.13 The most intense peak in the mass spectrum of 2,2-dimethylbutane is at m/z = 57. Propose a structure of this fragment ion (a.k.a. daughter ion).

Nutmeg Oil GC-MS Data Mass Spectrum of A M+ at 192 Compound is:

Nutmeg Oil GC-MS Data Mass Spectrum of B M+ at 208 Compound is: