Supporting Information of Green synthetic approach for synthesis of fluorescent carbon dots for lisinopril drug delivery system and their confirmations in the cells Vaibhavkumar N. Mehtaa,b, Shiva shankaran Chettiarc, Jigna R. Bhamorea, Suresh Kumar Kailasaa* and Ramesh M. Patelb aApplied chemistry Department, S. V. National Institute of Technology, Surat-395 007, India bASPEE SHAKILAM Agricultural Biotechnology Institute, Navsari Agricultural University, Surat-395007, India cDepartment of Biotechnology, Shree Ramkrishna Institute of Computer Education and Applied Sciences, Surat, India. *Corresponding author, Phone: +91-261-2201730; Fax: +91-261-2227334 E-mail: sureshkumarchem@gmail.com; skk@ashd.svnit.ac.in Figure S1. Fluorescence spectra of CDs in different solvents at excitation wavelength of 370 nm.

(a) (b) Figure S2. (a) UV-visible spectra of Lis-loaded CDs with the different ratios of CDs and lisinopril (b) photographs of Lis-loaded CDs with the different ratios of CDs and lisinopril under UV lamp at excitation wavelength of 365 nm.

(a) (b) (c) Figure S3. UV-visible spectra of Lis-loaded CDs is for the lisinopril drug release at PBS pH (a) 5.2, (b) 6.2 and (c) 7.4 at different time intervals.

Concentration (µg/mL) Cell viability (%) (a) Cell viability (%) (b) Figure S4. (a) MTT based cytotoxicity assay of HeLa cells after 24 h incubation with different concentration of CDs (10, 20, 50, 100, 200, 500, 750 and 1000 µg mL-1) and (b) cytotoxic effects of CDs, Lis-loaded CDs and free lisinopril.