Peres R. Badial, DVM, MSc, Ann M

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Presentation transcript:

Marjolin’s Ulcer in Two Horses with Hereditary Equine Regional Dermal Asthenia Peres R. Badial, DVM, MSc, Ann M. Rashmir-Raven, DVM, MS, DACVS, Didier Q. Cagnini, DVM, MSc, José P. Oliveira-Filho, DVM, PhD, Avery J. Cooley, DVM, DACVP, Paulo Henrique J. Cunha, DVM, PhD, Barbara E. Kitchell, DVM, PhD, Lissandro G. Conceição, DVM, PhD, Cathleen A. Mochal, DVM, Alexandre S. Borges, DVM, PhD Journal of Equine Veterinary Science Volume 33, Issue 7, Pages 515-522 (July 2013) DOI: 10.1016/j.jevs.2012.03.004 Copyright © 2013 Elsevier Inc. Terms and Conditions

Fig. 1 Skin wound of a Quarter Horse mare with hereditary equine regional dermal asthenia. (A) Atrophic scar at the right paralumbar region after the first topical treatment of the wound; the mare was 4 years old. (B) In subsequent years, the skin broke several times at the same region. (C) Progressive weight loss and wound deterioration of the mare on the day she was humanely euthanized; the mare was 10 years old. Journal of Equine Veterinary Science 2013 33, 515-522DOI: (10.1016/j.jevs.2012.03.004) Copyright © 2013 Elsevier Inc. Terms and Conditions

Fig. 2 Moderately differentiated squamous cell carcinoma. (A) Squamous cells at different stages arranged in irregular trabeculae and islets within a dense desmoplastic stroma (hematoxylin and eosin, 100×). (B) Nonkeratinized squamous cells arranged in trabeculae, demonstrating large, vesicular nuclei, prominent nucleoli, and mitotic figures (arrow). Cell islets with keratin pearls (arrow head) and a desmoplastic stroma can be observed (hematoxylin and eosin, 400×). Journal of Equine Veterinary Science 2013 33, 515-522DOI: (10.1016/j.jevs.2012.03.004) Copyright © 2013 Elsevier Inc. Terms and Conditions

Fig. 3 Immunohistochemistry. (A) Positive reaction to Ki-67 indicated by the presence of nuclear staining (arrow). (B) Nuclear p53 immunoreactivity can be seen in the neoplastic cells of tumor island (arrow). Journal of Equine Veterinary Science 2013 33, 515-522DOI: (10.1016/j.jevs.2012.03.004) Copyright © 2013 Elsevier Inc. Terms and Conditions

Fig. 4 Atrophic scar at the dorsal loin region of an 8-year-old Quarter Horse mare with hereditary equine regional dermal asthenia. Journal of Equine Veterinary Science 2013 33, 515-522DOI: (10.1016/j.jevs.2012.03.004) Copyright © 2013 Elsevier Inc. Terms and Conditions

Fig. 5 Chronic nonhealing wound on mare in Figure 4 shortly before euthanasia. Journal of Equine Veterinary Science 2013 33, 515-522DOI: (10.1016/j.jevs.2012.03.004) Copyright © 2013 Elsevier Inc. Terms and Conditions

Fig. 6 Large trabeculae of neoplastic squamous epithelial cells with some keratin pearls and focal connection with epidermis. Some necrotic lobules with neutrophilic infiltrates and inflamed desmoplastic stroma are also features. Journal of Equine Veterinary Science 2013 33, 515-522DOI: (10.1016/j.jevs.2012.03.004) Copyright © 2013 Elsevier Inc. Terms and Conditions

Fig. 7 Polyhedral nonkeratinized cells are present at the periphery of the neoplastic trabeculae, which display abundant premature and faulty keratinization at the center. Journal of Equine Veterinary Science 2013 33, 515-522DOI: (10.1016/j.jevs.2012.03.004) Copyright © 2013 Elsevier Inc. Terms and Conditions