From: Proteomic Profiling Reveals Adaptive Responses to Surgical Myocardial Ischemia–Reperfusion in Hibernating Arctic Ground Squirrels Compared to Rats.

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From: Proteomic Profiling Reveals Adaptive Responses to Surgical Myocardial Ischemia–Reperfusion in Hibernating Arctic Ground Squirrels Compared to Rats Anesthes. 2016;124(6):1296-1310. doi:10.1097/ALN.0000000000001113 Figure Legend: Proteomic analyses identified a significant increase in expression of myocardial sirtuin-3 (SIRT3) in arctic ground squirrel (AGS; both summer active [SA] and hibernating [HIB]) compared to rat, at every time point. Species differences also exist in the dynamic expression changes after ischemia–reperfusion injury (I/R): unlike rats, AGS recover their baseline SIRT3 levels by 24 h of reperfusion (R24h). Data are shown as mean ± SD, N = 6 to 8/group (A). Results were validated by Western blot and were corroborated with changes in proteins known to be regulated by SIRT3—up-regulation of manganese superoxide dismutase (MnSOD, T-total levels increased in AGS) and deacetylation of MnSOD (Ac-MnSOD levels decreased in AGS), which increase its reactive oxygen species scavenging activity. Extracellular signal–regulated kinase (ERK)1/2 is used as a loading control (B). *P < 0.05 by ANOVA with Tukey post hoc correction, relative to respective time point in the rat. R3h = 24 h of reperfusion; T-MnSOD = total manganese superoxide dismutase. Date of download: 11/7/2017 Copyright © 2017 American Society of Anesthesiologists. All rights reserved.